AYUNDA NAILA ZALIANTY, - (2026) PENETAPAN KADAR FENOL TOTAL, FLAVONOID TOTAL DAN AKTIVITAS ANTIOKSIDAN PADA PRODUK TONIKUM AKAR BAJAKAH KALALAWIT (Uncaria gambir Roxb.). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
![[img]](http://repository.stfi.ac.id/style/images/fileicons/text.png) |
Text
S_PSSF_A252077_Title.pdf Download (449kB) |
|
Text
S_PSSF_A252077_Chapter1.pdf Restricted to Repository staff only Download (283kB) |
|
Text
S_PSSF_A252077_Chapter2.pdf Restricted to Repository staff only Download (431kB) |
|
Text
S_PSSF_A252077_Chapter3.pdf Restricted to Repository staff only Download (344kB) |
|
Text
S_PSSF_A252077_Chapter4.pdf Restricted to Repository staff only Download (350kB) |
|
Text
S_PSSF_A252077_Chapter5.pdf Restricted to Repository staff only Download (257kB) |
|
Text
S_PSSF_A252077_Appendix.pdf Restricted to Repository staff only Download (901kB) |
Abstract
Kelelahan akibat aktivitas fisik dan stres oksidatif dapat meningkatkan pembentukan radikal bebas yang berperan dalam terjadinya penyakit degeneratif. Akar bajakah kalalawit (Uncaria gambir Roxb.) secara empiris digunakan masyarakat Kalimantan sebagai obat tradisional, namun belum banyak dibuat menjadi sediaan farmasi. Penelitian ini bertujuan memperoleh formula suspensi kering dari ekstrak etanol 96% akar bajakah kalalawit serta menentukan kadar fenol total, flavonoid total, aktivitas antioksidan, dan karakteristik fisiknya. Penetapan fenol total menggunakan metode Folin Ciocalteu, flavonoid total menggunakan metode AlCl₃, dan aktivitas antioksidan menggunakan metode DPPH, dengan analisis data melalui uji Spearman. Ekstrak memiliki fenol total 54,444 mg GAE/g, flavonoid total 7,957 mg QE/g, dan IC₅₀ 4,974 µg/ml. Formula 3 menunjukkan kadar fenol total, flavonoid total, dan aktivitas antioksidan tertinggi (56,000 mg GAE/g; 8,966 mg QE/g; IC₅₀ 5,853 µg/ml), dengan analisis statistik terhadap fenol, flavonoid serta aktivitas antioksidan menunjukkan adanya hubungan sangat kuat antar senyawa (0,8-1,00). Namun, dari segi karakteristik fisik, Formula 2 memiliki kadar air terendah, sudut diam terkecil, dan rasa yang masih dapat ditoleransi, sehingga dengan aktivitas antioksidan sangat kuat (IC₅₀ 7,252 µg/ml), Formula 2 dinyatakan sebagai formula paling potensial sebagai dasar pengembangan produk tonikum. ------- Fatigue from physical activity and oxidative stress can increase free radical formation, contributing to degenerative diseases. The kalalawit bajakah root (Uncaria gambir Roxb.) is traditionally used by the people of Kalimantan as a folk remedy, yet rarely developed into a pharmaceutical preparation. This study aimed to formulate a dry suspension from 96% ethanol extract of kalalawit bajakah root and determine its total phenolic content, total flavonoid content, antioxidant activity, and physical characteristics. Total phenolic content was measured using the Folin-Ciocalteu method, total flavonoid content using the AlCl₃ method, and antioxidant activity using the DPPH method, with data analyzed via the Spearman test. The extract showed a total phenolic content of 54.444 mg GAE/g, total flavonoid content of 7.957 mg QE/g, and an IC₅₀ of 4.974 µg/ml. Formula 3 had the highest phenolic content, flavonoid content, and antioxidant activity (56.000 mg GAE/g; 8.966 mg QE/g; IC₅₀ 5.853 µg/ml), with statistical analysis revealing a very strong correlation (0.8–1.00) among these parameters. However, based on physical characteristics, Formula 2 exhibited the lowest moisture content, smallest angle of repose, and tolerable taste. Given its strong antioxidant activity (IC₅₀ 7.252 µg/ml), Formula 2 was identified as the most potential formula for tonic product development.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | akar bajakah kalalawit, fenol total, flavonoid total, aktivitas antioksidan, suspensi kering. ----- bajakah kalalawit root, total phenolic content, total flavonoid content, antioxidant activity, dry suspension |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 24 Sep 2026 01:37 |
| Last Modified: | 24 Sep 2026 01:37 |
| URI: | http://repository.stfi.ac.id/id/eprint/4294 |
Actions (login required)
 |
View Item |
