KATHARINA CHYNTHIA CLARA CAHYANI, - (2026) PEMBENTUKAN KOMPLEKS PIPERIN INKLUSI NATRIUM KARAGENAN DAN UJI AKTIVITAS ANTIINFLAMASI DENGAN METODE CARRAGEENAN INDUCED PAW EDEMA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Piperin merupakan senyawa aktif dari Piper nigrum L. yang telah diketahui memiliki aktivitas antiinflamasi dan termasuk dalam Biopharmaceutics Classification System kelas II, sehingga diperlukan upaya peningkatan kelarutan melalui pembentukan kompleks inklusi menggunakan natrium karagenan sebagai matriks hidrofilik dari Eucheuma cottonii. Penelitian ini bertujuan memperoleh kompleks inklusi piperin natrium karagenan yang mampu meningkatkan kelarutan piperin serta mengevaluasi aktivitas antiinflamasinya menggunakan metode carrageenan induced paw edema. Kompleks inklusi dibuat dengan metode kopresipitasi pada perbandingan bobot 1:1. Evaluasi kompleks inklusi meliputi pengujian kadar air, karakterisasi menggunakan Fourier Transform Infrared, penetapan kadar piperin, serta uji kelarutan dalam air. Hasil penelitian menunjukkan bahwa kompleks inklusi memiliki kadar air sebesar 3,66±0,41% dan kadar piperin yang terjerap 98,76±2,90%. Hasil spektrum FTIR menunjukkan adanya interaksi non-kovalen antara piperin dan natrium karagenan tanpa pembentukan ikatan kovalen baru. Pembentukan kompleks inklusi berhasil meningkatkan kelarutan piperin dalam air sebesar 2,07 kali lipat. Aktivitas antiinflamasi dievaluasi secara in vivo pada tikus jantan yang diinduksi λ-karagenan 1%. Kompleks piperin inklusi natrium karagenan dosis 200 mg/kgBB menunjukkan aktivitas antiinflamasi yang lebih baik dibandingkan piperin 100 mg/kgBB dan asetosal 45 mg/kgBB (p<0,001). Dengan demikian, pembentukan kompleks piperin inklusi natrium karagenan berhasil meningkatkan kelarutan piperin dalam air dan memperkuat aktivitas antiinflamasi piperin. ------ Piperine is the bioactive compound of Piper nigrum L. that has anti-inflammatory activity and is classified as a Biopharmaceutics Classification System class II. Therefore, solubility enhancement strategies are required through the formation of an inclusion complex using sodium carrageenan as a hydrophilic matrix extracted from Eucheuma cottonii. This study aimed to develop a piperine–sodium carrageenan inclusion complex to improve the water solubility of piperine and evaluate anti-inflammatory activity using the carrageenan-induced paw edema model. The inclusion complex was prepared by the coprecipitation method at a 1:1 weight ratio of piperine to sodium carrageenan. The resulting complex was evaluated for moisture content, piperine content, water solubility, and characteristics using Fourier Transform Infrared spectroscopy. The results showed that the inclusion complex had a moisture content of 3.66 ± 0.41% and an entrapped piperine content of 98.76±2.90%. FTIR spectra indicated non-covalent interactions without the formation of new covalent bonds. The inclusion complex increased the water solubility of piperine by 2.07 times higher. The anti-inflammatory activity was evaluated in vivo after induction with 1% carrageenan. At a dose of 200 mg/kg body weight, the piperine–sodium carrageenan inclusion complex exhibited significantly anti-inflammatory activity than piperine (100 mg/kg body weight) and acetylsalicylic acid (45 mg/kg body weight) (p < 0.001). Overall, the piperine– sodium carrageenan inclusion complex successfully enhanced the water solubility and anti-inflammatory activity of piperine.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | piperin, natrium karagenan, inklusi, antiinflamasi. ------ piperine, inclusion, sodium carrageenan, antiinflammatory |
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 23 Sep 2026 08:02 |
| Last Modified: | 23 Sep 2026 08:02 |
| URI: | http://repository.stfi.ac.id/id/eprint/4292 |
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