GRACIA JOY SABONO, - (2026) UJI AKTIVITAS ANTI-DISLIPIDEMIA EKSTRAK DAN FRAKSI HERBA SIRIH CINA (Peperomia pellucida (L.) Kunth) PADA TIKUS WISTAR JANTAN YANG DIINDUKSI PAKAN TINGGI LEMAK DAN KARBOHIDRAT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Dislipidemia merupakan faktor risiko utama penyakit jantung koroner dan stroke yang prevalensinya di Indonesia masih tinggi akibat pola makan tinggi lemak dan karbohidrat. Herba sirih Cina (Peperomia pellucida (L.) Kunth) secara tradisional dimanfaatkan sebagai antikolesterol, namun kajian sistematis mengenai kontribusi masing-masing fraksinya terhadap profil lipid darah secara lengkap masih terbatas. Penelitian ini bertujuan untuk mengetahui aktivitas antidislipidemia ekstrak etanol dan fraksi (n-heksan, etil asetat, air) herba sirih Cina, menentukan fraksi paling efektif, serta menganalisis perbedaan efektivitas antar kelompok perlakuan. Penelitian bersifat eksperimental menggunakan Rancangan Acak Lengkap (RAL) dengan tujuh kelompok tikus Wistar jantan (kontrol normal, kontrol negatif, kontrol positif simvastatin 0,9 mg/kgBB, serta empat kelompok uji dosis 80 mg/kgBB) yang diinduksi dengan pakan tinggi lemak-karbohidrat disertai PTU 9 mg/kgBB selama 21 hari. Parameter kolesterol total, trigliserida, LDL, dan HDL dianalisis menggunakan One-Way ANOVA dan uji lanjut Tukey HSD. Hasil pengamatan menunjukkan bahwa seluruh ekstrak dan fraksi mampu menurunkan kolesterol total, trigliserida, dan LDL, serta meningkatkan HDL dibandingkan dengan kontrol negatif (p<0,05). Fraksi etil asetat menunjukkan aktivitas paling optimal (penurunan kolesterol total 45,16%, LDL 44,32%, peningkatan HDL 19,35%) dan tidak berbeda bermakna dengan simvastatin maupun kelompok lain (p>0,05). Disimpulkan bahwa ekstrak dan fraksi herba sirih Cina memiliki aktivitas antidislipidemia yang sebanding dengan simvastatin, dimana fraksi etil asetat menunjukan hasil paling optimal. ------ Dyslipidemia is a major risk factor for coronary heart disease and stroke, with persistently high prevalence in Indonesia linked to diets high in fat and carbohydrates. Sirih Cina herb (Peperomia pellucida (L.) Kunth) is traditionally used as a cholesterollowering agent, yet systematic studies on the contribution of its individual fractions to complete blood lipid profiles remain limited. This study aimed to evaluate the antidyslipidemic activity of the ethanol extract and fractions (n-hexane, ethyl acetate, water) of sirih Cina herb, identify the most effective fraction, and analyze differences in effectiveness among treatment groups. An experimental Completely Randomized Design (CRD) was applied with seven groups of male Wistar rats (normal control, negative control, positive control/simvastatin 0.9 mg/kgBW, and four test groups at 80 mg/kgBW) induced with a high-fat, high-carbohydrate diet plus PTU 9 mg/kgBW for 21 days. Total cholesterol, triglyceride, LDL, and HDL levels were analyzed using One-Way ANOVA followed by Tukey HSD post hoc test. All extract and fraction groups significantly reduced total cholesterol, triglyceride, and LDL, and increased HDL compared with the negative control (p<0.05). The ethyl acetate fraction showed the most optimal activity (45.16% reduction in total cholesterol, 44.32% reduction in LDL, 19.35% increase in HDL) with no significant difference from simvastatin or other groups (p>0.05). It is concluded that the extract and fractions of sirih Cina herb possess antidyslipidemic activity comparable to simvastatin, with the ethyl acetate fraction showing the most pronounced results.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | dislipidemia, Peperomia pellucida, fraksi etil asetat, profil lipid, tikus Wistar jantan ------ dyslipidemia, Peperomia pellucida, ethyl acetate fraction, lipid profile, Wistar rats |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 23 Sep 2026 07:38 |
| Last Modified: | 23 Sep 2026 07:38 |
| URI: | http://repository.stfi.ac.id/id/eprint/4289 |
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