MUTIARA AULIA PARMACITA, - (2026) ANALISIS KADAR FLAVONOID DAN UJI AKTIVITAS ANTIOKSIDAN EKSTRAK BIJI KEBIUL (Caesalpinia bonduc (L.) Roxb ) ASAL BENGKULU. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Biji kebiul (Caesalpinia bonduc (L.) Roxb.) merupakan salah satu tanaman obat tradisional yang diketahui mengandung berbagai senyawa metabolit sekunder, terutama flavonoid yang berpotensi sebagai antioksidan alami. Namun, informasi mengenai kadar flavonoid total dan aktivitas antioksidan ekstrak etanol biji kebiul asal Bengkulu masih terbatas. Penelitian ini bertujuan untuk mengetahui kandungan metabolit sekunder, menetapkan kadar flavonoid total, serta menentukan aktivitas antioksidan ekstrak etanol biji kebiul. Penelitian diawali dengan pembuatan simplisia, kemudian dilakukan ekstraksi dengan metode maserasi menggunakan pelarut etanol 96%. Ekstrak yang diperoleh selanjutnya dilakukan skrining fitokimia terhadap golongan alkaloid, flavonoid, tanin, saponin, steroid, dan terpenoid. Penetapan kadar flavonoid total dilakukan menggunakan metode spektrofotometri UV-Vis dengan pereaksi aluminium klorida (AlCl₃) 10% dan natrium asetat 1 M menggunakan kuersetin sebagai standar, sedangkan aktivitas antioksidan ditentukan menggunakan metode DPPH. Hasil penelitian menunjukkan bahwa simplisia dan ekstrak etanol biji kebiul positif mengandung alkaloid, flavonoid, tanin, dan saponin, sedangkan steroid dan terpenoid tidak terdeteksi. Kadar flavonoid total ekstrak etanol biji kebiul diperoleh sebesar 0,331 ± 0,005 mgQE/g, sedangkan aktivitas antioksidan sangat kuat dengan nilai IC₅₀ sebesar 15,135 ppm. Berdasarkan hasil tersebut, dapat disimpulkan bahwa ekstrak etanol biji kebiul asal Bengkulu menunjukkan kandungan flavonoid total dan aktivitas antioksidan yang sangat kuat. ------- Kebiul seeds (Caesalpinia bonduc (L.) Roxb.) are one of the traditional medicinal plants known to contain various secondary metabolites, particularly flavonoids, which have potential as natural antioxidants. However, information regarding the total flavonoid content and antioxidant activity of the ethanolic extract of Caesalpinia bonduc seeds from Bengkulu remains limited. This study aimed to identify the secondary metabolites, determine the total flavonoid content, and evaluate the antioxidant activity of the ethanolic extract of Caesalpinia bonduc seeds. The study was initiated by preparing the simplicia, followed by extraction using the maceration method with 96% ethanol as the solvent. The resulting extract was subjected to phytochemical screening for alkaloids, flavonoids, tannins, saponins, steroids, and terpenoids. The total flavonoid content was determined using the aluminum chloride (AlCl₃) colorimetric method with 10% AlCl₃ and 1 M sodium acetate reagents, employing quercetin as the standard and measured by UV-Visible spectrophotometry. Antioxidant activity was evaluated using the DPPH assay. The results showed that both the simplicia and the ethanolic extract of Caesalpinia bonduc seeds contained alkaloids, flavonoids, tannins, and saponins, while steroids and terpenoids were not detected. The total flavonoid content of the ethanolic extract was 0.331 ± 0.005 mg QE/g extract, whereas the extract exhibited very strong antioxidant activity with an IC₅₀ value of 15.135 ppm. Based on these findings, it can be concluded that the ethanolic extract of Caesalpinia bonduc seeds from Bengkulu contains flavonoids and exhibits very strong antioxidant activity
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | antioksidan, biji kebiul, DPPH, flavonoid total, spektrofotometri UV-Vis. ----- antioxidant, kebiul seeds, total flavonoid content, UV–Visible spectrophotometry |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 23 Sep 2026 07:10 |
| Last Modified: | 23 Sep 2026 07:10 |
| URI: | http://repository.stfi.ac.id/id/eprint/4283 |
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