PRETY JUNIFA ROSINDRI FOEH, - (2026) OPTIMASI FORMULA DAN EVALUASI TONER WAJAH ISOLAT KATEKIN DENGAN METODE SIMPLEX LATTICE DESIGN (SLD). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Isolat katekin dari Uncaria gambir Roxb. berpotensi dikembangkan sebagai bahan aktif dalam sediaan toner wajah karena memiliki aktivitas antioksidan yang tinggi. Karakteristik fisik toner dipengaruhi oleh komposisi eksipien, khususnya gliserin dan propilen glikol sebagai humektan. Penelitian ini bertujuan untuk mengetahui pengaruh variasi komposisi gliserin dan propilen glikol terhadap viskositas dan pH toner wajah isolat katekin serta memperoleh formula optimum menggunakan metode Simplex Lattice Design (SLD). Penelitian dilakukan menggunakan lima formula hasil rancangan Design Expert® versi 13 dengan variasi komposisi gliserin dan propilen glikol. Evaluasi meliputi organoleptik, homogenitas, pH, viskositas, optimasi formula, validasi model, cycling test, dan penetapan kadar katekin. Hasil penelitian menunjukkan bahwa kelima formula memiliki organoleptik yang baik, homogen, pH 5,28-5,53, dan viskositas 1,15-1,40 cP sehingga memenuhi persyaratan mutu toner. Variasi gliserin dan propilen glikol berpengaruh signifikan terhadap viskositas (p = 0,0035), tetapi tidak berpengaruh signifikan terhadap pH. Formula optimum diperoleh pada komposisi 11% gliserin dan 6% propilen glikol serta menunjukkan stabilitas fisik yang baik selama cycling test. Kesimpulan penelitian ini adalah variasi gliserin dan propilen glikol memengaruhi viskositas, tetapi tidak memengaruhi pH, serta formula optimum 11% gliserin dan 6% propilen glikol memenuhi persyaratan mutu dan memiliki stabilitas fisik yang baik. ------ Catechin isolates from Uncaria gambir Roxb. have the potential to be developed as active ingredients in facial toner formulations due to their high antioxidant activity. The physical characteristics of the toner are influenced by the composition of the excipients, particularly glycerin and propylene glycol as humectants. This study aimed to determine the effect of variations in the composition of glycerin and propylene glycol on the viscosity and pH of the catechin isolate facial toner and to identify the optimal formulation using the Simplex Lattice Design (SLD) method. The study was conducted using five formulas designed with Design Expert® version 13, varying the compositions of glycerin and propylene glycol. Evaluations included organoleptic testing, homogeneity, pH, viscosity, formula optimization, model validation, a cycling test, and determination of catechin content. The results showed that all five formulations exhibited good organoleptic properties, were homogeneous, had a pH of 5.28-5.53, and a viscosity of 1.15-1.40 cP, thereby meeting the quality requirements for a facial toner. Variations in glycerin and propylene glycol significantly affected viscosity (p = 0.0035) but did not significantly affect pH. The optimal formulation was obtained with a composition of 11% glycerin and 6% propylene glycol and demonstrated good physical stability during the cycling test. The conclusion of this study is that variations in glycerin and propylene glycol affect viscosity but do not affect pH, and that the optimal formulation of 11% glycerin and 6% propylene glycol meets quality requirements and exhibits good physical stability.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Katekin, Toner, SLD, Optimasi Formula. ----- Catechin, Toner, SLD, Formula Optimization. |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 23 Sep 2026 06:57 |
| Last Modified: | 23 Sep 2026 06:57 |
| URI: | http://repository.stfi.ac.id/id/eprint/4281 |
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