SYAFIRA RAKA BRILIANTARI, - (2026) PEMBUATAN MOLECULARLY IMPRINTED POLYMER (MIP) BERBASIS ASAM METAKRILAT DAN KATEKIN MENGGUNAKAN REAGEN PENGGANDENG COMU (1-Cyano-2-ethoxy-2-oxoethylidenaminooxy). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Metakriloil katekin merupakan senyawa flavonoid yang berpotensi sebagai monomer pada polimerisasi Molecularly Imprinted Polymer (MIP). Penelitian ini bertujuan mensintesis metakriloil katekin melalui reaksi esterifikasi menggunakan reagen penggandeng COMU, mengkarakterisasi metakriloil katekin yang dihasilkan, serta membuat Molecularly Imprinted Polymer (MIP). Proses pembuatan MIP dimulai dengan pembentukan monomer metakriloil katekin. Setelah pembentukan metakriloil katekin selanjutnya dilakukan proses pemurnian melalui ekstraksi cair-cair dan kromatografi kolom. Metakariloil katekin di karakterisasi menggunakan penentuan bilangan ester dengan hasil sebesar 215,44 mg KOH/g dengan Degree of Substitution (DS) 1,51 (-OH) dan Fourier Transform Infrared (FTIR) gugus karbonil ester pada pita serapan 1726,02 cm⁻¹. kemudian metakriloil katekin dipolimerisasi dengan menggunakan EGDMA sebagai crosslinker dan AIBN sebagai inisiator. Hasil polimerisasi MIP diamati dengan spektrum FTIR yang mengonfirmasi hilangnya gugus vinil (C=C) sehingga dapat disimpulkan bahwa metakriloil katekin berbasis asam metakrilat dan katekin berhasil disintesis menggunakan reagen penggandeng COMU yang kemudian akan digunakan untuk polimerisaai MIP. ------ Methacryloyl catechin is a flavonoid compound with potential as a monomer for the polymerization of Molecularly Imprinted Polymers (MIPs). This study aimed to synthesize methacryloyl catechin via an esterification reaction using the coupling reagent COMU, characterize the resulting methacryloyl catechin, and fabricate an MIP. The MIP fabrication process began with the formation of the methacryloyl catechin monomer. Following its formation, the product underwent purification via liquid-liquid extraction and column chromatography. Methacryloyl catechin was characterized by determining its ester value yielding 215.44 mg KOH/g with a Degree of Substitution (DS) of 1.51 (-OH groups) and by Fourier Transform Infrared (FTIR) spectroscopy, which detected the ester carbonyl group at an absorption band of 1726.02 cm⁻¹. Subsequently, the methacryloyl catechin was polymerized using EGDMA as a crosslinker and AIBN as an initiator. The MIP polymerization product was analyzed via FTIR spectroscopy, which confirmed the disappearance of the vinyl group (C=C); thus, it can be concluded that methacryloyl catechin derived from methacrylic acid and catechin was successfully synthesized using the COMU coupling reagent for subsequent use in polymerization of MIPs.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | katekin, metakriloil katekin, asam metakrilat, Molecularly Imprinted Polymer (MIP), COMU ------- catechin, methacryloyl catechin, methacrylic acid, Molecularly Imprinted Polymer (MIP), COMU |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 23 Sep 2026 03:22 |
| Last Modified: | 23 Sep 2026 03:22 |
| URI: | http://repository.stfi.ac.id/id/eprint/4274 |
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