FORMULASI DAN KARAKTERISASI FITOSOM α-MANGOSTIN MENGGUNAKAN SOYA LESITIN DENGAN METODE THIN-FILM HYDRATION

ALIN MARSHANDA PUTRI, - (2026) FORMULASI DAN KARAKTERISASI FITOSOM α-MANGOSTIN MENGGUNAKAN SOYA LESITIN DENGAN METODE THIN-FILM HYDRATION. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

α-Mangostin merupakan senyawa bioaktif utama dari kulit buah manggis (Garcinia mangostana L) yang memiliki aktivitas antioksidan dan berpotensi sebagai agen anti-aging, namun pemanfaatannya terbatas akibat kelarutan air, stabilitas, dan bioavailabilitas yang rendah. Pembentukan fitosom menggunakan soya lesitin sebagai sumber fosfatidilkolin diharapkan mampu meningkatkan karakteristik fisikokimia α-mangostin. Penelitian ini bertujuan untuk mengetahui pengaruh variasi rasio α-mangostin dan soya lesitin terhadap karakteristik fitosom serta menentukan formula optimum. Fitosom dibuat menggunakan metode thin film hydration dengan variasi rasio α-mangostin: soya lesitin yaitu 1:1 (F1), 1:1,5 (F2), 1:1,7 (F3), 1:2 (F4), dan 2:1 (F5), serta penambahan kolesterol sebesar 10mg. Karakterisasi meliputi pengamatan visual, ukuran partikel, indeks polidispersitas, zeta potensial, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), Entrapment Efficiency (EE), dan Loading Capacity (LC). Hasil penelitian menunjukkan bahwa Formula 3 (1:1,7) menghasilkan karakteristik terbaik dengan ukuran partikel 215,9 ± 11,8 nm, indeks polidispersitas 0,367 ± 0,037, zeta potensial -32,31 ± 0,88 mV, morfologi vesikel sferis, nilai EE 92,442 %, dan LC 31,615%. Analisis FTIR menunjukkan adanya interaksi antara α-mangostin dan fosfatidilkolin tanpa terbentuk gugus fungsi baru. Berdasarkan hasil tersebut dapat disimpulkan bahwa variasi rasio α-mangostin dan soya lesitin memengaruhi karakteristik fitosom, dengan Formula 3 (1:1,7) sebagai formula optimum. ------- α-Mangostin is a major bioactive compound derived from the pericarp of mangosteen (Garcinia mangostana L.) that exhibits antioxidant activity and shows potential as an anti-aging agent however, its utilization is limited by low water solubility, stability, and bioavailability. The formation of phytosomes using soya lecithin as a source of phosphatidylcholine is expected to improve the physicochemical characteristics of α-mangostin. This study aimed to determine the effect of varying the ratio of α-mangostin to soya lecithin on the characteristics of the phytosomes and to identify the optimum formula. Phytosomes were prepared using the thin-film hydration method with variations in the α-mangostin:soya lecithin ratio of 1:1 (F1), 1:1.5 (F2), 1:1.7 (F3), 1:2 (F4), and 2:1 (F5), along with the addition of 10 mg of cholesterol. Characterization included visual observation, particle size, polydispersity index, zeta potential, Fourier Transform Infrared Spectroscopy (FTIR), Transmission Electron Microscopy (TEM), Entrapment Efficiency (EE), and Loading Capacity (LC). The results showed that Formula 3 (1:1.7) produced the best characteristics, with a particle size of 215.9 ± 11.8 nm, a polydispersity index of 0.367 ± 0.037, a zeta potential of -32.31 ± 0.88 mV, spherical vesicle morphology, an EE value of 92,442%, and an LC value of 31,615% FTIR analysis revealed an interaction between α-mangostin and phosphatidylcholine without the formation of new functional groups. Based on these results, it can be concluded that variations in the ratio of α-mangostin to soya lecithin affect the characteristics of the phytosomes, with Formula 3 (1:1.7) identified as the optimum formula.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	α-mangostin, fitosom, fosfatidilkolin, thin film hydration, karakterisasi ------- α-mangostin, phytosome, phosphatidylcholine, thin film hydration, characterization.
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	22 Sep 2026 06:43
Last Modified:	22 Sep 2026 06:43
URI:	http://repository.stfi.ac.id/id/eprint/4266

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