FITRI RAHMAHDA YANTI, - (2026) PEMBUATAN MOLECULARLY IMPRINTED POLYMER (MIP) BERBASIS MONOMER HASIL ESTERIFIKASI KATEKIN DAN ASAM METAKRILAT MENGGUNAKAN REAGEN HATU. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Katekin merupakan senyawa polifenol alami dari golongan flavan-3-ols yang memiliki lima gugus hidroksil sehingga berpotensi dimodifikasi melalui reaksi esterifikasi dengan asam metakrilat untuk menghasilkan monomer fungsional sebagai bahan penyusun Molecularly Imprinted Polymer (MIP). Penelitian ini bertujuan memperoleh monomer hasil esterifikasi katekin dan asam metakrilat menggunakan reagen penggandeng HATU (O-(azabenzotriazol-1-il)-N,N,N’,Ntetrametiluronium heksafluorofosfat), mengkarakterisasi produk hasil sintesis, serta mensintesis polimer berbasis sintesis tersebut sebagai tahap awal pengembangan MIP berbasis katekin melalui metode polimerisasi presipitasi. Metakriloil katekin dimurnikan menggunakan metode ekstraksi cair-cair dan kromatografi kolom, kemudian dipantau menggunakan KLT, serta dikarakterisasi menggunakan Fourier Transform Infrared (FTIR), spektrofotometri UV-Vis, dan penentuan Degree of Substitution (DS). Hasil penelitian menunjukkan bahwa turunan metakriloil katekin berhasil disintesis, yang ditandai dengan munculnya pita karbonil ester C=O pada 1737,17 cm⁻¹ dan C–O ester pada 1128,03 cm⁻¹, spektrum UV-Vis menunjukkan adanya penambahan gugus kromofor pada metakriloil katekin, dan nilai bilangan ester sebesar 267,096 mg KOH/g, serta nilai derajat substitusi sebesar 2,06. Karakterisasi FTIR terhadap polimer menunjukkan hilangnya pita gugus vinil pada 1630,67 cm-1 dan 963,09 cm-1 . Berdasarkan hasil penelitian, reaksi esterifikasi katekin dan asam metakrilat menggunakan reagen HATU berhasil menghasilkan monomer fungsional yang digunakan dalam sintesis Molecularly Imprinted Polymer (MIP). ------ Catechin is a natural polyphenolic compound belonging to the flavan-3-ol group, containing five hydroxyl groups that can be modified through esterification with methacrylic acid to produce a functional monomer for Molecularly Imprinted Polymer (MIP). This study aimed to synthesize a monomer through esterification of catechin and methacrylic acid using HATU (O-(azabenzotriazol-1-yl)-N,N,N′,N′- tetramethyluronium hexafluorophosphate), characterize the synthesized product, and synthesize a polymer based on the resulting monomer as an initial stage in the development of catechin-based MIP using precipitation polymerization. Methacryloyl catechin was purified through liquid–liquid extraction and column chromatography, monitored using thin-layer chromatography (TLC), and characterized by Fourier Transform Infrared (FTIR) spectroscopy, UV–Vis spectrophotometry, and Degree of Substitution (DS) determination. The results indicated successful synthesis of methacryloyl catechin, demonstrated by the appearance of ester carbonyl (C=O) absorption at 1737.17 cm⁻¹ and ester C–O absorption at 1128.03 cm⁻¹. UV–Vis analysis indicated the addition of a chromophore group in methacryloyl catechin. The ester value was 267.096 mg KOH/g, with a DS of 2.06. FTIR characterization of the polymer showed disappearance of vinyl group absorption bands at 1630.67 cm⁻¹ and 963.09 cm⁻¹. Thus, esterification using HATU successfully produced a functional monomer subsequently used for MIP synthesis.
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | Asam metakrilat, HATU, katekin, metakriloil katekin, Molecularly Imprinted Polymer (MIP). ----- Methacrylic acid, HATU, Catechin, methacryloyl cathecin, Molecularly Imprinted Polymer (MIP) |
| Subjects: | Q Science > Q Science (General) Q Science > QD Chemistry |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 22 Sep 2026 03:21 |
| Last Modified: | 22 Sep 2026 03:21 |
| URI: | http://repository.stfi.ac.id/id/eprint/4263 |
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