FORMULASI NANOEMULSI PICKERING KATEKIN MENGGUNAKAN BOX-BEHNKEN DESIGN

DYTA KHARISMA PUTRI, - (2026) FORMULASI NANOEMULSI PICKERING KATEKIN MENGGUNAKAN BOX-BEHNKEN DESIGN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Katekin merupakan senyawa polifenol yang memiliki aktivitas farmakologis, namun memiliki stabilitas yang rendah akibat mudah mengalami degradasi oleh cahaya, oksigen, dan perubahan pH. Nanoemulsi Pickering merupakan sistem emulsi yang distabilkan oleh partikel padat pada antar muka minyak dan air. Penelitian ini bertujuan untuk memperoleh formula optimum nanoemulsi Pickering katekin menggunakan metode Box-Behnken Design (BBD). Nanoemulsi Pickering katekin diformulasikan menggunakan nanopartikel kitosan-tripolifosfat (TPP) sebagai penstabil Pickering. Faktor yang dioptimasi meliputi konsentrasi kitosantripolifosfat (TPP) (25–75%), gliserin (0–5%), dan MCT oil (0,5–2%), dengan respon persen transmitan. Formula optimum yang diperoleh selanjutnya divalidasi dan dikarakterisasi melalui pengujian organoleptik, pH, viskositas, sentrifugasi, ukuran droplet, indeks polidispersitas (PDI), dan zeta potensial. Hasil optimasi menunjukkan formula optimum terdiri atas kitosan-tripolifosfat (TPP) 25%, gliserin 0%, dan MCT oil 0,5% dengan nilai desirability sebesar 0,988. Hasil validasi menunjukkan nilai transmitan aktual sebesar 93,457 ± 0,238. Nilai viskositas yang diperoleh sebesar 1,153 ± 0,002 cP, pH 4,31 ± 0,000, ukuran droplet 570,4 nm, PDI 0,301, dan zeta potensial -40,39 mV. Hasil tersebut menunjukkan bahwa metode Box-Behnken Design berhasil digunakan untuk memperoleh formula optimum nanoemulsi Pickering katekin dengan karakteristik fisik yang baik dan stabil. ------ Catechin is a polyphenol compound that has pharmacological activity, but has low stability due to its easy degradation by light, oxygen, and pH changes. Pickering nanoemulsion is an emulsion system stabilized by solid particles at the oil-water interface. This study aims to obtain the optimum formula of catechin Pickering nanoemulsion using the Box-Behnken Design (BBD) method. The catechin Pickering nanoemulsion was formulated using chitosan-tripolyphosphate (TPP) nanoparticles as a Pickering stabilizer. The optimized factors include the concentration of chitosan-tripolyphosphate (TPP) (25–75%), glycerin (0–5%), and MCT oil (0.5–2%), with a response of percent transmittance. The optimum formula obtained was then validated and characterized through organoleptic testing, pH, viscosity, centrifugation, droplet size, polydispersity index (PDI), and zeta potential. The optimization results showed that the optimum formula consisted of 25% chitosan-tripolyphosphate (TPP), 0% glycerin, and 0.5% MCT oil with a desirability value of 0.988. The validation results showed an actual transmittance value of 93.457 ± 0.238. The viscosity value obtained was 1.153 ± 0.002 cP, pH 4.31 ± 0.000, droplet size 570.4 nm, PDI 0.301, and zeta potential -40.39 mV. These results indicate that the Box-Behnken Design method was successfully used to obtain the optimum formula of Pickering catechin nanoemulsion with good and stable physical characteristics.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Katekin, nanoemulsi Pickering, box-behnken design, Kitosan-TPP, Transmitan. ----- Catechin, Pickering nanoemulsion, Box–Behnken Design, chitosan-TPP, transmittance.
Subjects:	Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	19 Sep 2026 05:36
Last Modified:	19 Sep 2026 05:36
URI:	http://repository.stfi.ac.id/id/eprint/4257

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