FORMULASI NANOEMULSI PICKERING α-MANGOSTIN (Garcinia mangostana Linn) MENGGUNAKAN BOX-BEHNKEN DESIGN

MUTIARA ALHAMD, - (2026) FORMULASI NANOEMULSI PICKERING α-MANGOSTIN (Garcinia mangostana Linn) MENGGUNAKAN BOX-BEHNKEN DESIGN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

α-mangostin merupakan senyawa xanton utama dari kulit buah manggis (Garcinia mangostana Linn.) yang memiliki berbagai aktivitas farmakologis dan diperlukan sistem penghantaran yang mampu meningkatkan stabilitasnya. Nanoemulsi Pickering merupakan sistem emulsi yang distabilkan oleh partikel padat pada antarmuka minyak dan air. Penelitian ini bertujuan memperoleh formula optimum nanoemulsi Pickering α-mangostin menggunakan metode Box–Behnken Design (BBD). Nanoemulsi Pickering α-mangostin diformulasikan menggunakan nanopartikel kitosan-tripolifosfat (TPP) sebagai penstabil Pickering. Faktor yang dioptimasi meliputi konsentrasi minyak biji bunga matahari (0,5–2%), Tween 20 (0,5–2%), dan kitosan-TPP (25–75%), serta respon berupa persen transmitan. Formula optimum selanjutnya divalidasi dan dikarakterisasi. Hasil optimasi menunjukkan formula optimum terdiri atas minyak biji bunga matahari 0,5%, Tween 20 0,5%, dan kitosan-TPP 75% dengan nilai desirability 0,314. Nilai transmitan aktual sebesar 90,400 ± 0,265%, viskositas 3,77 ± 0,137 cP, pH 4,32, ukuran droplet 536,3 nm, PDI 0,8736, dan zeta potensial -12,19 mV. Hasil penelitian menunjukkan bahwa metode BBD dapat digunakan untuk memperoleh formula optimum nanoemulsi Pickering α-mangostin. ----- α-Mangostin is the major xanthone compound found in the pericarp of mangosteen (Garcinia mangostana Linn.) and exhibits a wide range of pharmacological activities. However, an appropriate drug delivery system is required to improve its stability. Pickering nanoemulsions are emulsion systems stabilized by solid particles adsorbed at the oil–water interface. This study aimed to obtain the optimum formulation of an α-mangostin Pickering nanoemulsion using the Box–Behnken Design (BBD) approach. The Pickering nanoemulsion was formulated using chitosan–tripolyphosphate (TPP) nanoparticles as the Pickering stabilizer. The formulation variables included sunflower seed oil (0.5–2%), Tween 20 (0.5–2%), and chitosan–TPP (25–75%), while percent transmittance was selected as the optimization response. The optimum formulation was subsequently validated and characterized. The optimization results indicated that the optimum formulation consisted of 0.5% sunflower seed oil, 0.5% Tween 20, and 75% chitosan–TPP, with a desirability value of 0.314. The characterization results showed a transmittance of 90.400 ± 0.265%, viscosity of 3.77 ± 0.137 cP, pH of 4.32, droplet size of 536.3 nm, polydispersity index (PDI) of 0.8736, and zeta potential of −12.19 mV. These findings demonstrate that the Box–Behnken Design approach is suitable for obtaining the optimum formulation of an α-mangostin Pickering nanoemulsion.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	α-mangostin, box-behnken design, kitosan-TPP, nanoemulsi Pickering, transmitan. ------ α-mangostin, box–behnken design, chitosan-TPP, Pickering nanoemulsion, transmittance.
Subjects:	Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	19 Sep 2026 05:26
Last Modified:	19 Sep 2026 05:26
URI:	http://repository.stfi.ac.id/id/eprint/4255

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