FORMULASI SPRAY NANOEMULSI GALANGAL OIL (Alpinia malaccensis (Burm.f.) DENGAN VARIASI RASIO SURFAKTAN

USWATUN KHASANAH, - (2026) FORMULASI SPRAY NANOEMULSI GALANGAL OIL (Alpinia malaccensis (Burm.f.) DENGAN VARIASI RASIO SURFAKTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Lengkuas (Alpinia malaccensis) menghasilkan minyak atsiri (galangal oil) yang berpotensi sebagai bahan aktif kosmetik brightening karena aktivitas antioksidan dan penghambatan tirosinase, namun sifatnya yang hidrofobik, volatil, dan mudah teroksidasi membatasi aplikasinya dalam sediaan berair. Penelitian ini bertujuan mempelajari pengaruh variasi rasio surfaktan Polysorbate 80 dan Sodium lauroyl sarcosinate terhadap karakteristik fisikokimia spray nanoemulsi galangal oil serta menentukan formula optimum. Nanoemulsi dibuat menggunakan metode high shear homogenization dengan lima variasi rasio surfaktan yang ditentukan melalui Simplex Lattice Design (Design Expert), kemudian dievaluasi meliputi organoleptik, transmitan, pH, viskositas, pola semprot, ukuran partikel, indeks polidispersitas (PDI), zeta potensial, dan cycling test enam siklus. Analisis ANOVA menunjukkan bahwa variasi rasio surfaktan berpengaruh signifikan terhadap seluruh respon (p<0,05) dengan nilai adjusted R² di atas 0,99. Hasil menunjukkan peningkatan proporsi Polysorbate 80 meningkatkan transmitan, memperkecil ukuran partikel, dan menurunkan PDI. Formula optimum diperoleh pada rasio Polysorbate 80:Sodium lauroyl sarcosinate 9:1 (F4) dengan desirability 1,000, transmitan 97,77%, pH 6,40, PDI 0,3554, ukuran partikel 172,20 nm, dan zeta potensial -25,85 mV. Formula ini stabil secara fisik tanpa pemisahan fase selama enam siklus cycling test. Disimpulkan bahwa rasio surfaktan memengaruhi karakteristik fisikokimia spray nanoemulsi galangal oil, dan rasio 9:1 menghasilkan formula dengan stabilitas dan karakteristik fisikokimia terbaik. ------ Galangal (Alpinia malaccensis) rhizome yields an essential oil (galangal oil) with reported antioxidant and tyrosinase-inhibitory activity, giving it potential as a brightening cosmetic active. However, its hydrophobic, volatile, and oxidationprone nature limits direct use in aqueous formulations. This study aimed to evaluate the effect of Polysorbate 80 and Sodium lauroyl sarcosinate ratio variation on the physicochemical characteristics of a galangal oil nanoemulsion spray and to determine the optimum formula. Nanoemulsions were prepared by high shear homogenization using five surfactant ratios generated via Simplex Lattice Design (Design Expert), then evaluated for organoleptic properties, transmittance, pH, viscosity, spray pattern, particle size, polydispersity index (PDI), zeta potential, and a six-cycle cycling test. ANOVA showed the surfactant ratio significantly affected all responses (p<0.05), with adjusted R² above 0.99. Increasing Polysorbate 80 proportion raised transmittance and reduced both particle size and PDI. The optimum formula, at a Polysorbate 80:Sodium lauroyl sarcosinate ratio of 9:1 (F4), achieved a desirability of 1.000, with transmittance 97.77%, pH 6.40, PDI 0.3554, particle size 172.20 nm, and zeta potential −25.85 mV, and remained physically stable with no phase separation through six cycling test cycles. The surfactant ratio was concluded to significantly influence the spray nanoemulsion's physicochemical properties.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	galangal oil; spray nanoemulsi; Polysorbate 80; Sodium lauroyl sarcosinate; Simplex Lattice Design. ---- galangal oil; nanoemulsion spray; Polysorbate 80; Sodium lauroyl sarcosinate; Simplex Lattice Design
Subjects:	R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	19 Sep 2026 02:42
Last Modified:	19 Sep 2026 02:42
URI:	http://repository.stfi.ac.id/id/eprint/4250

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