HAYKAL FIRGY SAPUTRA, - (2025) FORMULASI DAN EVALUASI TABLET EFFERVESCENT EKSTRAK QUINOA SEBAGAI ANTIOKSIDAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Quinoa (Chenopodium quinoa Willd.) memiliki kandungan metabolit sekunder flavonoid dan dikaitkan dalam aktivitas menangkal radikal bebas penyebab kanker pada konsentrasi (IC50) 0,47 ppm. Ekstrak quinoa memiliki aroma serta rasa yang tidak menyenangkan sehingga kurang diminati oleh pasien disegala usia. Tablet effervescent menjadi jawaban atas sistem penghantaran obat yang dipilih dengan memanfaatkan bahan tambahan untuk mengatasi rasa dan aroma ekstrak yang kurang menyenangkan. Bahan asam dan basa menentukan bagaimana tablet dapat larut dengan sempurna, maka variasi jumlah asam dan basa tiap formula perlu dilakukan evaluasi. Penelitian ini bertujuan untuk menentukan variasi komposisi yang baik antara asam sitrat, asam tartat, dan natrium bikarbonat pada tablet effervescent ekstrak quinoa serta mengetahui kekuatan aktivitas antioksidan pada tablet effervescent yang mengandung ekstrak quinoa. Penelitian ini menggunakan metode true experimental laboratorium, meliputi tahapan pembuatan ekstrak quinoa, uji aktivitas antioksidan metode DPPH menggunakan spektrofotometri UV-Vis, variasi jumlah asam dan basa dari 6 formula(45%, 50%, 55%, 60%, 65%, 70%) pada formulasi tablet effervescent ekstrak quinoa, serta evaluasi tablet. Uji aktivitas antioksidan dianalisis mengunakan spektrofotometri UV-Vis dengan persamaan linear dengan nilai absorbansi. Hasil evaluasi tablet dianalisis menggunakan SPSS (Statistical Program for Social Science) menggunakan uji normalitas Shapiro-Wilk, ANOVA, dan Kruskal-Wallis. Hasil penelitian menunjukan bahwa variasi jumlah asam dan basa berpengaruh terhadap evaluasi tablet. Semakin besar jumlah asam dan basa dapat meningkatkan waktu larut. Formula 6 dengan jumlah asam dan basa 70% merupakan formula yang memiliki waktu larut tercepat dan evaluasi yang memenuhi syarat seperti kandungan lembab 1,38%; kecepatan alir 9,62 gram/s, sudut diam 20,9o , waktu larut 3,14 menit; dan pH sebesar 5,85. ------ Quinoa (Chenopodium quinoa Willd.) contains flavonoid secondary metabolites and is associated with the activity of warding off cancer-causing free radicals at a concentration (IC50) of 0.47 ppm. Quinoa extract has an unpleasant aroma and taste, making it less popular among patients of all ages. Effervescent tablets are the answer to the chosen drug delivery system by utilizing additional ingredients to overcome the unpleasant taste and aroma of the extract. Acidic and basic ingredients determine how the tablet can dissolve completely, so variations in the amount of acid and base in each formula need to be evaluated. This study aims to determine the good composition variations between citric acid, tartaric acid, and sodium bicarbonate in quinoa extract effervescent tablets and to determine the strength of antioxidant activity in effervescent tablets containing quinoa extract. This study used a true experimental laboratory method, including the stages of making quinoa extract, testing the antioxidant activity of the DPPH method using UV-Vis spectrophotometry, variations in the amount of acid and base from 6 formulas (45%, 50%, 55%, 60%, 65%, 70%) in the formulation of quinoa extract effervescent tablets, and tablet evaluation. The antioxidant activity test was analyzed using UV-Vis spectrophotometry with a linear equation with the absorbance value. The results of the tablet evaluation were analyzed using SPSS (Statistical Program for Social Science) using the Shapiro-Wilk, ANOVA, and Kruskal-Wallis normality tests. The results of the study showed that variations in the amount of acid and base affected the tablet evaluation. The greater the amount of acid and base, the longer the dissolution time. Formula 6 with 70% acid and base was the formula with the fastest dissolution time and met the evaluation requirements, such as a moisture content of 1.38%; a flow rate of 9.62 grams/s, an angle of repose of 20.9°, a dissolution time of 3.14 minutes; and a pH of 5.85.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Quinoa, Antioksidan, Asam sitrat, Asam tartrat, Natrium Bikarbonat. ------- Quinoa, Antioxidants, Citric Acid, Tartaric Acid, Sodium Bicarbonate |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 09 Dec 2025 01:35 |
| Last Modified: | 09 Dec 2025 01:35 |
| URI: | http://repository.stfi.ac.id/id/eprint/3552 |
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