MUHAMMAD NAUFAL ALIFFY FIRDAUS, - (2025) STUDI AKTIVITAS MUKOLITIK DEKOKTA KOMBINASI JAHE MERAH (Zingiber officinale var. rubrum) DAN DAUN KEMANGI (Ocimum sanctum L.) SECARA IN VITRO. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Batuk berdahak merupakan kondisi yang ditandai dengan penumpukan mukus berlebih sehingga membutuhkan terapi mukolitik untuk membantu pengenceran dahak. Penelitian ini bertujuan untuk mengetahui aktivitas mukolitik dekokta kombinasi jahe merah (Zingiber officinale var. rubrum) dan daun kemangi (Ocimum sanctum L.) terhadap viskositas putih telur bebek secara in vitro, serta menentukan konsentrasi optimal yang memberikan efektivitas terbaik. Metode penelitian dilakukan dengan pembuatan dekokta jahe merah (5%, 10%, 20%) dan daun kemangi (2,5%, 5%, 10%), kemudian dikombinasikan dengan variasi perbandingan (1:1, 1:3, 3:1). Uji aktivitas mukolitik dilakukan dengan pengukuran viskositas menggunakan viskometer Brookfield pada interval waktu 0, 15, 30, 45, dan 60 menit. Hasil penelitian menunjukkan bahwa dekokta jahe merah, daun kemangi, maupun kombinasinya memiliki aktivitas mukolitik dengan penurunan viskositas yang signifikan dibandingkan kontrol negatif. Aktivitas mukolitik meningkat seiring dengan kenaikan konsentrasi, dengan efektivitas tertinggi diperoleh pada jahe merah 20% dan kombinasi jahe merah–kemangi perbandingan 3:1, yang hasilnya hampir mendekati kontrol positif (asetilsistein). Dengan demikian, kombinasi jahe merah dan daun kemangi berpotensi dikembangkan sebagai agen mukolitik alami. ------- Productive cough is characterized by excessive mucus accumulation, which requires mucolytic therapy to facilitate sputum liquefaction. This study aimed to evaluate the mucolytic activity of a decoction of red ginger (Zingiber officinale var. rubrum) and basil leaves (Ocimum sanctum L.) on the viscosity of duck egg white in vitro, as well as to determine the optimal concentration that provides the best effectiveness. The decoctions were prepared at various concentrations of red ginger (5%, 10%, 20%) and basil leaves (2.5%, 5%, 10%), then combined at different ratios (1:1, 1:3, 3:1). Mucolytic activity was assessed by measuring viscosity using a Brookfield viscometer at time intervals of 0, 15, 30, 45, and 60 minutes. The results showed that red ginger, basil leaf decoctions, and their combinations exhibited mucolytic activity with significant viscosity reduction compared to the negative control. Mucolytic activity increased with higher concentrations, with the highest effectiveness observed in red ginger 20% and the red ginger–basil combination at a 3:1 ratio, which were almost comparable to the positive control (acetylcysteine). Therefore, the combination of red ginger and basil leaves has potential to be developed as a natural mucolytic agent.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Jahe merah, daun kemangi, dekokta, mukolitik, viskositas, in vitro. ------- Red ginger, basil leaves, decoction, mucolytic, viscosity, in vitro |
| Subjects: | Q Science > Q Science (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 25 Nov 2025 01:45 |
| Last Modified: | 25 Nov 2025 01:45 |
| URI: | http://repository.stfi.ac.id/id/eprint/3550 |
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