DWI HARIYANTI, - (2025) ISOLASI DAN KARAKTERISASI FISIKA PADATAN SELULOSA DARI SERBUK PENGGERGAJIAN KAYU SEBAGAI EKSIPIEN SEDIAAN SOLID. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Serbuk gergaji kayu merupakan hasil pengolahan kayu yang diketahui mengandung selulosa yang berpotensi untuk dimanfaatkan. Selulosa dapat dijadikan alternatif bahan baku eksipien farmasi. Penelitian ini bertujuan untuk mengisolasi selulosa dari serbuk penggergajian kayu dan mengkarakterisasi profil fisika padatannya sebagai alternatif pilihan eksipien sediaan solid. Isolasi dilakukan melalui tahapan delignifikasi menggunakan NaOH 20%, hidrolisis menggunakan HCl 2N dan bleaching menggunakan H2O2 20%. Selulosa hasil isolasi kemudian dikarakterisasi meliputi organoleptik, identifikasi iodin zinc-chloride, pH, kelarutan, LOD, laju alir, sudut diam, kompresibilitas, kadar abu, SEM, AAS dan FTIR, serta pengujian profil fisika padatan diantaranya kerapatan sejati, solid fraction, tensile strength, bonding index, dan BFI. Hasil penelitian menunjukkan selulosa hasil isolasi memiliki profil fisika padatan yang serupa dengan literatur selulosa komersial. Ditandai dengan karakteristik padatan selulosa menunjukkan kerapatan sejati (1,281 g/cm3 ), solid fraction ( 0,31), bonding index (0,045) dan BFI (0,075) yang sesuai literatur. Dalam pengujian tensile strength, sampel menunjukkan nilai rendah (0,26 MPa), sehingga tablet manual cenderung rapuh. FTIR mengonfirmasi hasil isolasi selulosa serbuk penggergajian kayu serupa dengan standar, sedangkan SEM menunjukkan morfologi berupa struktur serat panjang yang tidak homogen. Sehingga dapat disimpulkan bahwa, selulosa serbuk penggergajian kayu berpotensi digunakan sebagai alternatif pilihan eksipien tablet terutama sebagai bahan pengisi atau penghancur tambahan, dan diperlukan optimasi metode isolasi termasuk tahap formulasi untuk mengetahui lebih dalam performanya. ------- Wood sawdust is a wood processing product known to contain cellulose that has the potential to be utilized. Cellulose can be used as an alternative raw material for pharmaceutical excipients. This study aims to isolate cellulose from wood sawdust and characterize its solid physical profile as an alternative choice of excipient for solid preparations. Isolation was carried out through delignification using 20% NaOH, hydrolysis using 2N HCl, and bleaching using 20% H2O2. The isolated cellulose was then characterized in terms of organoleptic properties, zinc-chloride iodine identification, pH, solubility, LOD, flow rate, angle of repose, compressibility, ash content, SEM, AAS, and FTIR, as well as solid physical profile testing, including true density, solid fraction, tensile strength, bonding index, and BFI. The results showed that the isolated cellulose had a solid physical profile similar to that of commercial cellulose in the literature. Characterized by solid cellulose characteristics, it had a true density (1.281 g/cm3), solid fraction (0.31), bonding index (0.045), and BFI (0.075) that were consistent with the literature. In tensile strength testing, the samples showed low values (0.26 MPa), making manual tablets prone to brittleness. FTIR confirmed that the results of wood sawdust cellulose powder isolation were similar to the standard, while SEM showed a morphology in the form of a non-homogeneous long fiber structure. Thus, it can be concluded that wood sawdust cellulose powder has the potential to be used as an alternative tablet excipient, especially as a filler or additional disintegrant, and optimization of the isolation method, including the formulation stage, is needed to further understand its performance.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | selulosa, serbuk gergaji kayu, eksipien, tablet, karakteristik fisika padatan. ------- cellulose, wood sawdust, excipients, tablets, physical characteristics of solids |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 20 Nov 2025 07:30 |
| Last Modified: | 20 Nov 2025 07:30 |
| URI: | http://repository.stfi.ac.id/id/eprint/3546 |
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