ANNISA PUTRI DEWANTARA, - (2025) FORMULASI DAN EVALUASI SEDIAAN TABLET HISAP ISOLAT KURKUMIN DENGAN VARIASI KONSENTRASI POLIVINIL PIROLIDON (PVP) SEBAGAI PENGIKAT TERHADAP SIFAT FISIK TABLET. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Industri farmasi terus berinovasi dalam mengembangkan sediaan obat yang praktis untuk meningkatkan kepatuhan pasien, terutama bagi pasien yang kesulitan menelan tablet konvensional. Tablet hisap menjadi alternatif sediaan oral yang mudah digunakan tanpa air dan memiliki onset kerja lebih cepat karena absorpsi zat aktif melalui mukosa mulut. Penelitian ini bertujuan untuk mengetahui pengaruh variasi konsentrasi Polivinil Pirolidon (PVP) sebagai bahan pengikat terhadap sifat fisik tablet hisap isolat kurkumin serta menentukan konsentrasi PVP yang optimal. Tablet hisap diformulasikan dengan metode granulasi basah menggunakan variasi konsentrasi PVP yaitu 1% ,2%, 3%, 4%, dan 5%. Evaluasi meliputi uji organoleptis, keseragaman bobot, keseragaman ukuran, kekerasan, kerapuhan, dan waktu larut. Hasil penelitian menunjukkan bahwa peningkatan konsentrasi PVP berpengaruh terhadap kualitas fisik tablet. Semakin tinggi konsentrasi PVP, kekerasan tablet meningkat dan kerapuhan menurun, namun waktu larut menjadi lebih lama. Semua formula menghasilkan tablet hisap dengan kualitas fisik yan baik. Hasil evaluasi menunjukkan bahwa isolat kurkumin dapat diformulasikan menjadi tablet hisap yang memenuhi persyaratan mutu fisik tablet. Namun, sifat higroskopis tablet menunjukkan perlunya penelitian lanjutan terkait peningkatan stabilitas terhadap kelembapan melalui modifikasi formulasi atau penggunaan bahan pelapis yang sesuai. ------- The pharmaceutical industry continues to innovate in developing practical drug preparations to improve patient compliance, especially for patients who have difficulty swallowing conventional tablets. Lozenges are an alternative oral preparation that is easy to use without water and has a faster onset of action due to absorption of the active substance through the oral mucosa. This study aims to determine the effect of variations in the concentration of Polyvinyl Pyrolidone (PVP) as a binder on the physical properties of curcumin isolate lozenges and to determine the optimal PVP concentration. Lozenges were formulated by the wet granulation method using various PVP concentrations of 1%, 2%, 3%, 4%, and 5%. Evaluation included organoleptic tests, weight uniformity, size uniformity, hardness, friability, and dissolution time. The results showed that increasing the PVP concentration affected the physical quality of the tablets. The higher the PVP concentration, the tablet hardness increased and friability decreased, but the dissolution time became longer. All formulas produced lozenges with good physical quality. The evaluation results showed that curcumin isolate can be formulated into lozenges that meet the physical quality requirements of tablets. However, the hygroscopic nature of the tablets indicates the need for further research regarding increasing stability to moisture through formulation modification or the use of suitable coating materials.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | kurkumin, Polivinil Pirolidon (PVP), tablet hisap. ------ curcumin, Polyvinyl Pyrolidone (PVP), lozenges. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 20 Nov 2025 07:24 |
| Last Modified: | 20 Nov 2025 07:24 |
| URI: | http://repository.stfi.ac.id/id/eprint/3545 |
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