NEZA ALYA SOFA, - (2025) UJI KARAKTERISASI KOMBINASI POLIMER POLYVINYL PIROLIDON (PVP K-30) DAN POLYVINYL ALCOHOL (PVA) SEBAGAI MATRIKS MICRONEEDLE. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Salah satu inovasi yang berkembang dalam sistem penghantaran obat transdermal adalah penggunaan microneedle, yaitu jarum berukuran mikron yang dapat menembus lapisan stratum korneum tanpa menimbulkan rasa sakit. Penelitian ini bertujuan untuk mengetahui dan mendapatkan karakteristik hasil evaluasi fisik untuk matriks microneedle, khususnya kombinasi Polyvinyl Pirolidon (PVP K-30) dan Polyvinyl Alcohol (PVA) dengan ukuran microneedle yang dibuat rasio perbesaran lima kali. Metode penelitian menggunakan teknologi 3D Printing sebagai alat untuk mencetak molding microneedle, pembuatan microneedle menggunakan PVP K-30 dan PVA sebagai matriks microneedle, serta uji karakterisasi microneedle. Hasil penelitian menunjukkan bahwa kombinasi polimer PVP K-30 dan PVA menghasilkan nilai viskositas sebesar 187,5 cPs, nilai ini menghasilkan aliran yang mudah dituang pada saat proses pencetakan ke dalam molding microneedle. Microneedle yang dihasilkan dari kombinasi polimer PVP K-30 dan PVA menunjukkan bahwa microneedle mampu menembus hingga delapan lapisan Parafilm®M, menandakan memiliki kekuatan mekanik yang cukup untuk menembus kulit tanpa patah. Dengan demikian dapat disimpulkan kombinasi polimer PVP K-30 dan PVA dapat digunakan sebagai matriks microneedle. -------- One of the emerging innovations in transdermal drug delivery systems is the use of microneedles, micron-sized needles capable of penetrating the stratum corneum layer without causing pain. This study aims to determine and obtain the physical evaluation characteristics of microneedle matrices, particularly the combination of Polyvinylpyrrolidone (PVP K-30) and Polyvinyl Alcohol (PVA), using microneedles fabricated at a fivefold magnification ratio. The research method employed 3D printing technology to create microneedle molds, while the microneedles themselves were prepared using PVP K-30 and PVA as matrix materials, followed by microneedle characterization tests. The results showed that the combination of PVP K-30 and PVA polymers produced a viscosity value of 187.5 cPs, which allowed for easy flow during the molding process. The microneedles formed from this polymer combination demonstrated the ability to penetrate up to eight layers of Parafilm® M, indicating sufficient mechanical strength to pierce the skin without breaking. Therefore, it can be concluded that the combination of PVP K-30 and PVA can be effectively used as a microneedle matrix.
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | Microneedle, PVA, PVP, karakteristik fisik. ------- Microneedle, PVA, PVP, physical characteristics. |
| Subjects: | Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 20 Nov 2025 04:31 |
| Last Modified: | 20 Nov 2025 04:31 |
| URI: | http://repository.stfi.ac.id/id/eprint/3530 |
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