STEFAN SURYAJAYA, - (2025) KARAKTERISASI DISPERSI PADAT AMORF KURKUMIN MENGGUNAKAN POLIMER POLYVINYL PYROLIDONE (PVP) K-30 DENGAN METODE SOLVENT EVAPORATION. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Kurkumin diklasifikasikan sebagai senyawa kelas IV pada sistem Biopharmaceutical Classification System (BCS) karena kelarutan dan permeabilitasnya yang rendah. Untuk mengatasi masalah tersebut, dilakukan teknik dispersi padat amorf dengan metode solvent evaporation. Karena bentuk amorf bersifat tidak stabil dan mudah mengalami rekristalisasi, digunakan polimer PVP K-30 sebagai pembawa untuk membentuk amorphous solid dispersion (ASD). Penelitian ini bertujuan untuk mengkarakterisasi sistem dispersi padat kurkumin– PVP K-30 dalam meningkatkan kelarutan dan stabilitas kurkumin. Dispersi padat dibuat dengan variasi rasio kurkumin:PVP K-30 (1:1; 1:3; 1:5; 1:7; dan 1:9 b/b) menggunakan metode solvent evaporation. Karakterisasi dilakukan dengan Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), dan Fourier Transform Infrared Spectroscopy (FTIR). Hasil PXRD menunjukkan penurunan kristalinitas menjadi bentuk amorf pada seluruh formula dibandingkan kurkumin murni. Analisis DSC memperlihatkan pergeseran titik leleh ke suhu lebih rendah, yaitu 45,72°C; 41,72°C; 43,20°C; 39,68°C; dan 45,42°C, yang menandakan perubahan sifat termal. Spektrum FTIR menunjukkan pergeseran bilangan gelombang pada gugus hidroksil (O–H) yang mengindikasikan terbentuknya ikatan hidrogen antara kurkumin dan PVP K-30. Secara keseluruhan, hasil penelitian menunjukkan bahwa PVP K-30 mampu mendispersikan kurkumin dengan baik dalam bentuk amorf sehingga berpotensi meningkatkan kelarutan dan stabilitasnya. ----- Curcumin is classified as a Class IV compound in the Biopharmaceutical Classification System (BCS) due to its low solubility and permeability. To overcome this problem, an amorphous solid dispersion technique was performed using the solvent evaporation method. Since the amorphous form is inherently unstable and prone to recrystallization, polyvinylpyrrolidone (PVP) K-30 was used as a polymer carrier to stabilize the amorphous form. This study aimed to characterize curcumin–PVP K-30 solid dispersion systems to improve the solubility and stability of curcumin. The solid dispersions were prepared with various curcumin:PVP K30 ratios (1:1, 1:3, 1:5, 1:7, and 1:9 w/w) using the solvent evaporation method. Characterization was performed using Powder X-Ray Diffraction (PXRD), Differential Scanning Calorimetry (DSC), and Fourier Transform Infrared Spectroscopy (FTIR). PXRD results indicated a reduction in crystallinity, confirming the transformation of curcumin into an amorphous form in all formulations compared to pure curcumin. DSC analysis revealed a shift in melting points to lower temperatures (45.72°C, 41.72°C, 43.20°C, 39.68°C, and 45.42°C), indicating thermal property changes. FTIR spectra showed shifts in hydroxyl (O– H) stretching bands, suggesting hydrogen bond formation between curcumin and PVP K-30. Overall, these findings demonstrate that PVP K-30 successfully dispersed curcumin into an amorphous form, thereby potentially enhancing its solubility and stability.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Kurkumin, PVP K-30, Dispersi Padat, Karakterisasi. ------ Curcumin, PVP K-30, Solid Dispersion, Characterization |
| Subjects: | Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 20 Nov 2025 03:49 |
| Last Modified: | 20 Nov 2025 03:49 |
| URI: | http://repository.stfi.ac.id/id/eprint/3527 |
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