ELISA FEBRIANI, - (2025) IDENTIFIKASI DRUG RELATED PROBLEMS (DRPs) PADA PENGOBATAN PASIEN TUBERKULOSIS PARU DI RSUD BANDUNG KIWARI PROVINSI JAWA BARAT PERIODE 2024. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Tuberkulosis (TB) merupakan penyakit infeksi kronis yang disebabkan oleh Mycobacterium tuberculosis dan masih menjadi masalah kesehatan global utama. Indonesia menempati urutan ketiga kasus TB terbanyak di dunia setelah India dan Filipina. Pengobatan TB memerlukan kombinasi beberapa obat dalam jangka waktu lama sehingga berpotensi menimbulkan Drug Related Problems (DRPs). Penelitian ini bertujuan untuk mengidentifikasi kejadian DRPs serta menganalisis faktor yang berhubungan dengan DRPs pada pasien TB paru di RSUD Bandung Kiwari. Penelitian ini menggunakan metode observasional dengan desain retrospektif melalui penelusuran rekam medis pasien TB periode Januari–Desember 2024. Data dianalisis menggunakan uji Chi-Square untuk melihat hubungan antara variabel demografis dan klinis dengan kejadian DRPs. Dari total 104 pasien, ditemukan 45 pasien (43,3%) mengalami DRPs. Kategori DRPs terbanyak adalah reaksi obat yang merugikan (44,44%), ketidakpatuhan (24,45%), dan ketidaktepatan dosis (31,1%). Hasil uji statistik menunjukkan bahwa jenis kelamin dan umur tidak berhubungan signifikan dengan DRPs (p>0,05), namun penyakit penyerta memiliki hubungan yang sangat signifikan (p<0,001). Kesimpulannya, penyakit penyerta seperti diabetes melitus dan hipertensi merupakan faktor utama yang memengaruhi kejadian DRPs pada pasien TB paru. ----- Tuberculosis (TB) is a chronic infectious disease caused by Mycobacterium tuberculosis and remains a major global health problem. Indonesia ranks third in the world for TB cases after India and the Philippines. TB treatment requires a combination of several drugs over a long period, potentially causing Drug-Related Problems (DRPs). This study aims to identify the incidence of DRPs and analyze factors associated with DRPs in pulmonary TB patients at Bandung Kiwari Regional Hospital. This study used an observational method with a retrospective design through a search of TB patient medical records from January–December 2024. Data were analyzed using the Chi-Square test to examine the relationship between demographic and clinical variables and the incidence of DRPs. Of the total 104 patients, 45 patients (43.3%) experienced DRPs. The most common DRP categories were adverse drug reactions (44.44%), non-compliance (24.45%), and inappropriate dosage (31.1%). Statistical test results showed that gender and age were not significantly associated with DRPs (p>0.05), but comorbidities were highly significant (p<0.001). In conclusion, comorbidities such as diabetes mellitus and hypertension are the main factors influencing the occurrence of DRPs in pulmonary TB patients.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Tuberkulosis paru, Drug Related Problems, OAT, penyakit penyerta, RSUD Bandung Kiwari. ------ Pulmonary tuberculosis, Drug-Related Problems, Anti-TB Drugs, comorbidities, Bandung Kiwari Regional Hospital. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RA Public aspects of medicine |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 19 Nov 2025 02:28 |
| Last Modified: | 19 Nov 2025 02:28 |
| URI: | http://repository.stfi.ac.id/id/eprint/3485 |
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