KADJUL FIRDA CHALIA, - (2025) FORMULASI DAN EVALUASI NANOEMULSI ISOLAT ALFA MANGOSTIN DENGAN BASIS MINYAK BIJI BUNGA MATAHARI (Helianthus annuus L.). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Nanoemulsi merupakan sistem partikulat koloid dengan diameter tetesan rata-rata berkisar antara 50 hingga 1000 nm sebagai sistem penghantaran obat yang dapat meningkatkan efikasi serta efisiensi dosis sehingga efek samping obat berkurang. Penelitian ini bertujuan untuk mengetahui karakteristik dari nanoemulsi isolat mangostin dengan variasi basis minyak biji bunga matahari dan polisorbat 80 sebagai surfaktan serta sorbitol sebagai kosurfaktan. Penelitian dilakukan terhadap tiga formula nanoemulsi, yaitu Formula 1 (5 %), Formula 2 (10%), dan Formula 3 (15%). Evaluasi meliputi parameter fisik (organoleptis, pH, viskositas, daya sebar, daya lekat) pada penyimpanan selama 28 hari serta uji lanjutan pada formula terbaik yaitu uji particle size analyzer dan uji stabilitas fisik. Hasil penelitian menunjukkan formula 1 sebagai formula terbaik dengan pH 6,85–4,88, viskositas 975,00 cPs ± 25 – 1216,66 cPs ± 596,51, daya sebar 5,33 ± 0,090 cm, daya lekat 12,66 detik, dan ukuran droplet 94,66 ± 5,13 nm – 126,00 ± 122. Formula 1 merupakan formula paling optimal karena menunjukkan kestabilan fisik paling baik pada uji masa simpan dan uji stabilitas fisik. ------ Nanoemulsions are colloidal particulate systems with an average droplet diameter ranging from 50 to 1000 nm, serving as drug delivery systems that can improve efficacy and dose efficiency, thereby reducing adverse drug effects. This study aimed to evaluate the characteristics of alpha mangostin isolate nanoemulsions using sunflower seed oil as the oil phase, polysorbate 80 as the surfactant, and sorbitol as the cosurfactant. Three nanoemulsion formulas were prepared, namely Formula 1 (5%), Formula 2 (10%), and Formula 3 (15%). The evaluation included physical parameters (organoleptic properties, pH, viscosity, spreadability, and adhesiveness) during on storage for 28 days, followed by further testing of the best formula using a particle size analyzer and an accelerated stability test. The results showed that Formula 1 was the best formula with pH ranging from 6,85 to 4,88, viscosity of 975,00 cPs ± 25 – 1216,66 cPs ± 596,51, spreadability of 5,33 ± 0,090 cm, adhesiveness of 12,66 seconds, and droplet size of 94,66 ± 5,13 nm – 126,00 ± 122. Formula 1 was recommended as the most optimal formulation since it exhibited the best physical stability during storage and physical stability testing.
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | alfa mangostin, minyak biji bunga matahari, stabilitas, particle size. ------ alpha-mangostin, sunflower seed oil, stability, particle size. |
| Subjects: | Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 19 Nov 2025 02:24 |
| Last Modified: | 19 Nov 2025 02:24 |
| URI: | http://repository.stfi.ac.id/id/eprint/3484 |
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