RIKA SEPTIANI, - (2025) PENGARUH KOMBINASI PENGISI PADA TABLET KUNYAH BIJI QUINOA (Chenopodium quinoa W.) DAN BIJI CHIA (Salvia hispanica L.) SEBAGAI SUPLEMEN SERAT MENGGUNAKAN METODE SIMPLEX LATTICE DESIGN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
![[img]](http://repository.stfi.ac.id/style/images/fileicons/text.png) |
Text
S_PSSF_A211113_Title.pdf Download (316kB) |
|
Text
S_PSSF_A211113_Chapter1.pdf Restricted to Repository staff only Download (96kB) |
|
Text
S_PSSF_A211113_Chapter2.pdf Restricted to Repository staff only Download (344kB) |
|
Text
S_PSSF_A211113_Chapter3.pdf Restricted to Repository staff only Download (117kB) |
|
Text
S_PSSF_A211113_Chapter4.pdf Restricted to Repository staff only Download (317kB) |
|
Text
S_PSSF_A211113_Chapter5.pdf Restricted to Repository staff only Download (32kB) |
|
Text
S_PSSF_A211113_Appendix.pdf Restricted to Repository staff only Download (1MB) |
Abstract
Kebutuhan serat pangan harian masyarakat umumnya belum terpenuhi, sehingga diperlukan alternatif sediaan yang praktis dan mudah dikonsumsi, salah satunya dalam bentuk tablet kunyah berbahan dasar kaya serat seperti biji quinoa (Chenopodium quinoa Willd.) dan biji chia (Salvia hispanica L.). Penelitian ini bertujuan untuk mengetahui pengaruh kombinasi manitol dan sukrosa sebagai bahan pengisi pada tablet kunyah berbasis biji quinoa dan biji chia, serta menentukan formula optimum menggunakan metode Simplex Lattice Design (SLD) yang menghasilkan delapan variasi formula dengan konsentrasi pengisi yang berbeda. Proses formulasi dilakukan dengan metode granulasi basah, kemudian dilakukan evaluasi terhadap sifat massa cetak granul (distribusi ukuran partikel, laju alir, kompresibilitas, dan kerapatan sejati) serta karakteristik tablet (keseragaman ukuran dan bobot, kekerasan, friabilitas, friksibilitas, dan kandungan serat). Analisis menggunakan SLD menghasilkan formula optimum dengan komposisi manitol 21,6% dan sukrosa 26,4% dengan nilai desirability sebesar 1,000, dan hasil verifikasi menunjukkan kesesuaian dengan data aktual. Secara umum, manitol cenderung menghasilkan granul dengan aliran yang kurang baik dan tablet dengan kekerasan lebih rendah, sedangkan sukrosa meningkatkan plastisitas dan kekerasan tablet namun bersifat lebih higroskopis. Kombinasi keduanya terbukti memberikan efek sinergis terhadap karakteristik fisik tablet. Hasil uji kadar serat menunjukkan kandungan serat total sebesar 13,12%, sehingga tablet kunyah ini berpotensi dikembangkan sebagai suplemen serat lebih lanjut. ------ The daily dietary fiber intake among the population generally remains insufficient, highlighting the need for alternative dosage forms that are practical and easy to consume. One such form is chewable tablets made from fiber-rich ingredients such as quinoa seeds (Chenopodium quinoa Willd.) and chia seeds (Salvia hispanica L.). This study aimed to evaluate the effect of mannitol and sucrose combinations as filler materials in quinoa- and chia-based chewable tablets and to determine the optimum formulation using the Simplex Lattice Design (SLD) method, which generated eight formulations with varying filler concentrations. The formulation process was carried out using the wet granulation method, followed by evaluations of granule properties (particle size distribution, flow rate, compressibility, and true density) and tablet characteristics (uniformity of size and weight, hardness, friability, friction, and fiber content). The SLD analysis produced an optimum formula containing 21.6% mannitol and 26.4% sucrose with a desirability value of 1.000, and the verification results showed good agreement with the experimental data. In general, mannitol tended to produce granules with poorer flowability and tablets with lower hardness, while sucrose enhanced tablet plasticity and hardness but was more hygroscopic. The combination of both fillers demonstrated a synergistic effect on the physical properties of the tablets. The fiber content test showed a total fiber content of 13.12%, indicating that this chewable tablet has the potential to be further developed as a dietary fiber supplement.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Manitol, Sukrosa, Biji Quinoa, Biji Chia, Simplex Lattice Design. ----- Manitol, Sucrose, Quinoa Seeds, Chia Seeds, Simplex Lattice Design |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 19 Nov 2025 02:07 |
| Last Modified: | 19 Nov 2025 02:07 |
| URI: | http://repository.stfi.ac.id/id/eprint/3480 |
Actions (login required)
 |
View Item |
