RHINDIAN ANGELLIA, - (2025) AKTIVITAS ANTI-TUKAK MINYAK KUNYIT (Curcuma longa L.) PADA MODEL TUKAK LAMBUNG AKIBAT INDUKSI ASETOSAL PADA TIKUS WISTAR JANTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Tukak lambung merupakan kelainan pada saluran cerna akibat ketidakseimbangan antara faktor agresif dan defensif mukosa lambung. Salah satu penyebab utamanya adalah penggunaan asetosal (asam asetilsalisilat) yang dapat mengiritasi mukosa. Kunyit (Curcuma longa L.) diketahui mengandung senyawa kurkumin dengan aktivitas antiinflamasi dan antioksidan yang berpotensi memberikan efek protektif terhadap mukosa lambung. Penelitian ini bertujuan untuk mengetahui aktivitas antitukak minyak kunyit terhadap tikus putih jantan galur Wistar yang diinduksi asetosal. Penelitian dilakukan secara eksperimental menggunakan enam kelompok hewan uji: kontrol normal, kontrol negatif (asetosal), kontrol positif (omeprazol 1,76 mg/kgBB), serta tiga kelompok perlakuan minyak kunyit dengan dosis 100, 500, dan 1000 mg/kgBB secara oral. Parameter yang diamati meliputi pH lambung, indeks tukak, tingkat keparahan, dan histopatologi. Hasil penelitian menunjukkan bahwa minyak kunyit mampu meningkatkan pH lambung, menurunkan jumlah serta keparahan tukak secara signifikan (p < 0,05), dan memperbaiki struktur mukosa lambung dengan gambaran histologis yang mendekati normal. Dosis 500 mg/kgBB dan 1000 mg/kgBB memberikan efek yang sebanding dengan omeprazol dengan persentase inhibisi tukak sebesar 75%. Disimpulkan bahwa minyak kunyit memiliki aktivitas antitukak yang signifikan dan berpotensi sebagai agen gastroprotektif alami. ------ Gastric ulcer is a gastrointestinal disorder caused by an imbalance between aggressive and defensive factors of the gastric mucosa. One of the main causes is the use of asetosal (acetylsalicylic acid), which irritates the gastric lining. Turmeric (Curcuma longa L.) contains curcumin compounds with anti-inflammatory and antioxidant properties that may provide protective effects on gastric mucosa. This study aimed to evaluate the anti-ulcer activity of turmeric oil against asetosalinduced gastric ulcers in male Wistar rats. The experimental study involved six groups of animals: normal control, negative control (asetosal), positive control (omeprazole 1,76 mg/kgBW), and three treatment groups receiving turmeric oil at doses of 100, 500, and 1000 mg/kgBW orally. The observed parameters included gastric pH, ulcer index, ulcer severity, and histopathological changes. The results showed that turmeric oil significantly (p < 0.05) increased gastric pH, reduced ulcer number and severity, and improved mucosal histology compared to the negative control. Doses of 500 mg/kgBW and 1000 mg/kgBW demonstrated protective effects comparable to omeprazole, with an ulcer inhibition percentage of 75%. It can be concluded that turmeric oil exhibits significant anti-ulcer activity and has potential as a natural gastroprotective agent.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | anti-tukak, asetosal, Curcuma longa L., minyak kunyit, tikus wistar. ----- anti-ulcer, asetosal, Turmeric oil, Wistar rats. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 18 Nov 2025 03:04 |
| Last Modified: | 18 Nov 2025 03:04 |
| URI: | http://repository.stfi.ac.id/id/eprint/3471 |
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