FORMULASI SEDIAAN CLAY MASK ISOLAT MANGOSTIN SEBAGAI ANTIJERAWAT

SHAFA NURUL FADILLA, - (2025) FORMULASI SEDIAAN CLAY MASK ISOLAT MANGOSTIN SEBAGAI ANTIJERAWAT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Jerawat merupakan peradangan kulit yang umum dialami remaja dan disebabkan oleh pertumbuhan bakteri Propionibacterium acnes. Penelitian ini bertujuan untuk menentukan konsentrasi hambat minimum (KHM) isolat mangostin, mengembangkan formulasi clay mask isolat mangostin, serta mengevaluasi aktivitas antibakterinya terhadap Propionibacterium acnes. Uji KHM dilakukan dengan metode difusi cakram menggunakan konsentrasi 0,275%, 0,55%, dan 1,1%, sedangkan formulasi clay mask dibuat dengan kombinasi basis bentonite dan kaolin dalam empat variasi konsentrasi. Evaluasi sediaan meliputi organoleptik, pH, homogenitas, viskositas, waktu mengering, daya sebar, daya lekat, dan uji stabilitas cycling test. Hasil penelitian menunjukkan KHM isolat mangostin sebesar 0,275% dengan zona hambat 15,10±0,64 mm. Seluruh formula memenuhi syarat evaluasi dan stabil secara fisik. Uji aktivitas antibakteri menunjukkan bahwa formula 1 memiliki zona hambat sebesar 9,18±0,76 mm, formula 2 sebesar 8,83±0,93 mm, formula 3 sebesar 7,00±0,46 mm, dan formula 4 sebesar 7,33±0,97 mm. Berdasarkan hasil tersebut, clay mask isolat mangostin memiliki potensi sebagai sediaan topikal antijerawat alami. ------ Acne is a common inflammatory skin disorder among adolescents and is caused by the growth of Propionibacterium acnes bacteria. This study aimed to determine the minimum inhibitory concentration (MIC) of mangosteen isolate, develop clay mask formulations containing mangosteen isolate, and evaluate their antibacterial activity against Propionibacterium acnes. The MIC test was conducted using the disc diffusion method with concentrations of 0.275%, 0.55%, and 1.1%, while clay mask formulations were prepared using combinations of bentonite and kaolin bases in four concentration variations. Formulation evaluation included organoleptic properties, pH, homogeneity, viscosity, drying time, spreadability, adhesiveness, and cycling test stability. The results showed that the MIC of mangosteen isolate was 0.275% with an inhibition zone of 15.10±0.64 mm. All formulas met the evaluation requirements and were physically stable. The antibacterial activity test showed that formula 1 had an inhibition zone of 9.18±0.76 mm, formula 2 had 8.83±0.93 mm, formula 3 had 7.00±0.46 mm, and formula 4 had 7.33±0.97 mm. Based on these results, the mangosteen isolate clay mask has potential as a natural topical anti-acne preparation.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	antibakteri, clay mask, jerawat, mangostin, Propionibacterium acnes. ------ antibacterial, clay mask, acne, mangosteen, Propionibacterium acnes.
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	17 Nov 2025 07:24
Last Modified:	17 Nov 2025 07:24
URI:	http://repository.stfi.ac.id/id/eprint/3466

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