ZULFA FARAH FADILLA, - (2025) FORMULASI DAN EVALUASI FISIK SEDIAAN TONER WAJAH ISOLAT ALFA-MANGOSTIN SEBAGAI ANTIJERAWAT DENGAN VARIASI SURFAKTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Acne vulgaris merupakan penyakit kulit kronis yang banyak dialami remaja maupun dewasa, salah satu penyebab utamanya adalah Propionibacterium acnes. Terapi konvensional dengan antibiotik topikal seringkali menimbulkan resistensi dan efek samping, sehingga diperlukan alternatif berbasis bahan alam. Alfamangostin, senyawa xanton utama dari kulit buah manggis, diketahui memiliki aktivitas antibakteri terhadap P. acnes. Penelitian ini bertujuan untuk memformulasikan sediaan toner wajah berbasis isolat alfa-mangostin dengan variasi surfaktan Polysorbate 20, Polysorbate 40, dan Polysorbate 80 serta mengevaluasi kestabilan fisika-kimia dan aktivitas antibakterinya. Formulasi dilakukan dengan melarutkan alfa-mangostin menggunakan variasi surfaktan dengan bantuan sonikasi dan penambahan bahan tambahan. Evaluasi meliputi uji organoleptis, homogenitas, viskositas, pH, kestabilan kadar melalui cycling test, serta uji aktivitas antibakteri menggunakan difusi cakram. Hasil penelitian menunjukkan seluruh formula memenuhi kriteria stabilitas organoleptis dan viskositas, meskipun kadar alfa-mangostin menurun setelah enam siklus penyimpanan. Formula dengan Polysorbate 20 memberikan kestabilan terbaik dibandingkan Polysorbate 40 dan Polysorbate 80. Aktivitas antibakteri terlihat pada ketiga formula terhadap P. acnes, dengan zona hambat rata-rata: formula 1 sebesar 17,33 ± 0,614 mm, formula 2 sebesar 15,93 ± 0,862 mm, dan formula 3 sebesar 17,21 ± 0,718 mm. Dengan demikian, toner alfa-mangostin menggunakan Polysorbate 20 berpotensi dikembangkan secara optimal sebagai produk kosmetik antijerawat berbasis bahan alam. ------ Acne vulgaris is a chronic skin disorder commonly experienced by both adolescents and adults, with Propionibacterium acnes being one of its main causative agents. Conventional therapy with topical antibiotics often leads to resistance and side effects, thus requiring alternative treatments derived from natural sources. Alphamangostin, the major xanthone compound from mangosteen peel, is known to possess antibacterial activity against P. acnes. This study aimed to formulate a facial toner preparation based on alpha-mangostin isolate using different surfactants Polysorbate 20, Polysorbate 40, and Polysorbate 80 and to evaluate its physicochemical stability and antibacterial activity. The formulation was carried out by dissolving alpha-mangostin with the surfactant variations, assisted by sonication and the addition of excipients. Evaluation included organoleptic tests, homogeneity, viscosity, pH, chemical stability by cycling test, and antibacterial activity using the disc diffusion method. The results showed that all formulas met the criteria for organoleptic stability and viscosity, although alpha-mangostin levels decreased after six storage cycles. The formulation with Polysorbate 20 exhibited the best stability compared to Polysorbate 40 and Polysorbate 80. Antibacterial activity was demonstrated by all three formulas against P. acnes, with average inhibition zones of 17.33 ± 0.614mm for formula 1, 15.93 ± 0.862mm for formula 2, and 17.21 ± 0.718mm for formula 3. Thus, the alpha-mangostin toner formulated with Polysorbate 20 shows potential for optimal development as a natural-based anti-acne cosmetic product.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Antijerawat, alfa-mangostin, toner wajah, surfaktan, stabilitas. ---- Anti-acne, alpha-mangostin, facial toner, surfactant, stability |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 17 Nov 2025 06:25 |
| Last Modified: | 17 Nov 2025 06:25 |
| URI: | http://repository.stfi.ac.id/id/eprint/3459 |
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