SAFIRA NATANAELIA, - (2023) UJI AKTIVITAS ANTIBAKTERI EKSTRAK ETANOL KULIT BUAH JERUK DEKOPON (Citrus reticulata B.) TERHADAP BAKTERI Propionibacterium acne DAN Staphylococcus epidermidis. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Jerawat merupakan salah satu penyakit kulit yang hampir dialami sebagian besar penduduk (90%) mulai remaja hingga dewasa. Salah satu tanaman yang dapat berkhasiat sebagai antibakteri yaitu tanaman jeruk dekopon (Citrus reticulata B..). Tumbuhan ini mengandung metabolit sekunder berupa flavonoid, alkaloid, terpenoid, dan minyak atsiri yang dapat digunakan sebagai antibakteri. Tujuan dari penelitian ini yaitu untuk mengetahui aktivitas antibakteri ekstrak etanol kulit buah jeruk dekopon terhadap bakteri Propionibacterium acne dan Staphylococcus epidermidis. Ekstrak etanol kulit buah jeruk dekopon diperoleh dengan cara maserasi menggunakan etanol 50%, 70%, dan 96% yang menghasilkan rendemen sebanyak 29,38%, 28,01% dan 24,01%. Mikrodilusi digunakan untuk mementukan Konsentrasi Hambat Minimum (KHM), sedangkan dilusi agar digunakan untuk menentukan Konsentrasi Bunuh Minimum (KBM). Ekstrak etanol 50%, 70% dan 96% kulit buah jeruk dekopon menunjukkan nilai KHM terhadap Propionibacterium acne sebesar 2000 ppm, sedangkan nilai KHM terhadap Staphylococcus epidermidis pada rentang 1000 – 2000 ppm. Keempat ekstrak memiliki KBM terhadap Propionibacterium acne dan Staphylococcus epidermidis sebesar 16.000 ppm dan 32.000 ppm. Ekstrak etanol 50%, 70% dan 96% kulit buah jeruk dekopon dapet disimpulkan memiliki potensi dalam menghambat pertumbuhan Propionibacterium acne dan Staphylococcus epidermidis. --- Acne is a skin disease that is almost experienced by most of the population (90%) from adolescents to adults. One of the plants that can be efficacious as an antibacterial is the dekopon orange plant (Citrus reticulata B.). This plant contains secondary metabolites in the form of flavonoids, alkaloids, terpenoids, and essential oils that can be used as antibacterials. The purpose of this study was to determine the antibacterial activity of ethanol extract of dekopon orange peel against Propionibacterium acne and Staphylococcus epidermidis bacteria. Ethanol extract from dekopon orange peel was obtained by maceration using 50%, 70%, and 96% ethanol which produced yields of 29.38%, 28.01%, and 24.01%. Microdilution was used to determine the Minimum Inhibitory Concentration (MIC), while agar dilution was used to determine the Minimum Bactericidal Concentration (MBC). The 50%, 70%, and 96% ethanol extracts of dekopon orange peel showed a MIC value against Propionibacterium acne of 2000 pm. While 50%, 70%, and 96% ethanol extracts of dekopon orange peel showed MIC values against Staphylococcus epidermidis of 1000 - 2000 ppm. MBC against Propionibacterium acne and Staphylococcus epidermidis amounted to 16,000 ppm and 32,000 ppm. It can be concluded that 50%, 70%, and 96% ethanol extracts of dekopon orange peel have the potential to inhibit the growth of Propionibacterium acne and Staphylococcus epidermidis.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Jeruk dekopon, Propionibacterium acne, Staphylococcus epidermidis, KHM, KBM Citrus decopon, Propionibacterium acne, Staphylococcus epidermidis, MIC, MBC |
| Subjects: | R Medicine > RS Pharmacy and materia medica R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 24 Jun 2024 02:35 |
| Last Modified: | 25 Jun 2024 01:21 |
| URI: | http://repository.stfi.ac.id/id/eprint/293 |
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