RISQIA RUNI TRIANA, - (2025) AKTIVITAS ANTI-HIPERLIPIDEMIA EKSTRAK DAN FRAKSI (AIR, ETIL ASETAT, DAN N-HEKSAN) DAUN KIRINYUH (Chromolaena odorata L.) DENGAN INDUKSI PAKAN TINGGI LEMAK PADA TIKUS WISTAR JANTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Hiperlipidemia merupakan salah satu faktor risiko utama penyakit kardiovaskular yang ditandai dengan peningkatan kadar lipid dalam darah. Simvastatin dikenal efektif menurunkan kolesterol, namun penggunaan jangka panjang dapat menimbulkan efek samping. Daun kirinyuh (Chromolaena odorata L.) mengandung flavonoid, tanin, dan saponin yang berpotensi sebagai agen antihiperlipidemia alami. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol dan fraksi n-heksan, etil asetat, serta air daun kirinyuh terhadap kadar kolesterol total pada tikus Wistar jantan yang diinduksi pakan tinggi lemak. Sebanyak 35 ekor tikus dibagi menjadi tujuh kelompok, yaitu kontrol normal, kontrol negatif, kontrol positif (simvastatin 0,9 mg/KgBB), ekstrak etanol, fraksi air, fraksi etil asetat, dan fraksi n-heksan. Induksi hiperlipidemia dilakukan menggunakan pakan tinggi lemak dan propiltiourasil (PTU), kemudian perlakuan diberikan selama 21 hari dengan dosis 60 mg/kgBB. Kadar kolesterol total diukur pada hari ke-0, ke-7, ke-14, dan ke-21 menggunakan metode CHOD-PAP. Hasil penelitian menunjukkan bahwa seluruh perlakuan ekstrak dan fraksi daun kirinyuh mampu menurunkan kadar kolesterol secara signifikan dibandingkan kontrol negatif, namun tidak ada perbedaan bermakna dengan kontrol positif(p <0,05). Fraksi etil asetat memberikan penurunan tertinggi sebesar 68,84% pada hari ke-21, mendekati efektivitas simvastatin. Temuan ini mendukung potensi daun kirinyuh, khususnya fraksi etil asetat, sebagai kandidat fitofarmaka untuk terapi alternatif hiperlipidemia. ------ Hyperlipidemia is a major risk factor for cardiovascular disease, characterized by elevated blood lipid levels. Simvastatin is effective in lowering cholesterol; however, long-term use may cause adverse effects. Chromolaena odorata L. leaves contain flavonoids, tannins, and saponins, which have potential as natural antihyperlipidemic agents. This study aimed to evaluate the antihyperlipidemic activity of ethanol extract and its n-hexane, ethyl acetate, and aqueous fractions in male Wistar rats fed a high-fat diet. Thirty-five rats were divided into seven groups: normal control, negative control, positive control (simvastatin 0,9 mg/ kg body weight), ethanol extract, aqueous fraction, ethyl acetate fraction, and n-hexane fraction. Hyperlipidemia was induced using a high-fat diet and propylthiouracil (PTU), followed by 21 days of treatment at a dose of 60 mg/kg body weight. Total cholesterol levels were measured on days 0, 7, 14, and 21 using the CHOD-PAP method. All treatments significantly reduced cholesterol levels compared to the negative control, but there was no significant difference with the positive control (p < 0.05). The ethyl acetate fraction showed the highest reduction (68.84%) on day 21, comparable to simvastatin. These findings indicate that C. odorata leaves, particularly the ethyl acetate fraction, have potential as phytopharmaceutical candidates for alternative hyperlipidemia therapy.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Chromolaena odorata L., kolesterol, antihiperlipidemia, fraksinasi. ------ Chromolaena odorata L.,cholesterol, antihyperlipidemia, fractionation |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 09 Sep 2025 01:40 |
| Last Modified: | 09 Sep 2025 01:40 |
| URI: | http://repository.stfi.ac.id/id/eprint/2770 |
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