RAHMAWATI, - (2025) FORMULASI DAN EVALUASI GRANUL INSTAN EKSTRAK DAUN SUKUN (Artocarpus altilis (parkinson) fosberg), ROSELLA (Hibiscus sabdariffa L.) DAN KOMBINASINYA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Daun sukun dan rosella mengandung senyawa aktif seperti flavonoid, fenol dan antosianin yang berperan sebagai antioksidan serta antikolesterol. Penelitian ini bertujuan untuk mengembangkan sediaan granul instan yang diharapkan memiliki kepraktisan penggunaan yang baik. Granul diformulasikan dalam enam variasi, terdiri dari tiga formula ekstrak daun sukun tunggal dan tiga kombinasi daun sukun–rosella kode DE3C dengan perbandingan pengisi laktosa dan manitol 1:2, 2:1, dan 1:1 menggunakan metode granulasi basah. Evaluasi mencakup uji mutu simplisia, skrining fitokimia, serta pengujian fisik granul. Hasil skrining menunjukkan adanya flavonoid, fenol, dan saponin pada kedua ekstrak. Evaluasi granul menghasilkan pH 4,36–5,89, distribusi partikel (fines) 4,1–9,4%, kelembaban 0,70–1,47%, laju alir 29–36,4 gram/detik, sudut istirahat 4,7–5,96°, kompresibilitas 6,3–11,8%, dan waktu melarut 1,11–1,17 menit. Uji hedonik menunjukkan Formula 4 paling disukai panelis pada atribut rasa, aroma, dan bentuk. Nilai ini dipengaruhi campuran bahan yang lebih homogen sehingga rasa asam rosella lebih seimbang. Hasil penelitian membuktikan granul instan daun sukun–rosella memenuhi standar kualitas granul. ----- Sukun and rosella leaves contain active compounds such as flavonoids, phenols, and anthocyanins, which act as antioxidants and anticholesterol agents. This study aims to develop an instant granule formulation that is expected to have good practicality of use. The granules were formulated in six variations, consisting of three single sukun leaf extract formulas and three sukun–rosella combinations coded DE3C with lactose and mannitol filler ratios of 1:2, 2:1, and 1:1 using the wet granulation method. The evaluation included crude drug quality testing, phytochemical screening, and physical testing of the granules. The screening results showed the presence of flavonoids, phenols, and saponins in both extracts. The granule evaluation yielded pH values of 4.36–5.89, particle distribution (fines) of 4.1–9.4%, moisture content of 0.70–1.47%, flow rate of 29–36.4 grams/second, angle of repose of 4.7–5.96°, compressibility of 6.3–11.8%, and dissolution time of 1.11–1.17 minutes. The hedonic test showed that Formula 4 was the most preferred by the panelists in terms of taste, aroma, and shape. This value was influenced by a more homogeneous mixture of ingredients, resulting in a more balanced rosella acid taste. The research results proved that the instant sukun–rosella granules met the quality standards for granules.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | daun sukun, rosella, granul instan, uji hedonik. ----- sukun leaves, rosella, instant granules, hedonic test. |
| Subjects: | Q Science > Q Science (General) Q Science > QH Natural history > QH301 Biology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 04 Sep 2025 03:49 |
| Last Modified: | 04 Sep 2025 03:49 |
| URI: | http://repository.stfi.ac.id/id/eprint/2764 |
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