NGURAH KURNIA KRISTIAN, - (2025) EVALUASI FISIK DISPERSI PADAT AMORF α-MANGOSTIN DENGAN POLIMER POLYVINYL PYRROLIDONE (PVP) K-30 MENGGUNAKAN METODE SOLVENT EVAPORATION. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
α-mangostin memiliki aktivitas biologis yang luas, tapi kelarutannya dalam air sangat rendah sehingga membatasi bioavailabilitasnya. Penelitian ini bertujuan untuk mengevaluasi sifat fisik dari sistem dispersi padat amorf (DPA) α-mangostin menggunakan polimer polyvinyl pyrrolidone (PVP) K-30 yang diformulasikan dengan metode solvent evaporation. Tiga formula DPA dengan rasio α-mangostin : PVP K-30 sebesar 1:1, 1:3, dan 1:5 diuji melalui evaluasi kelarutan, profil disolusi, dan stabilitas fisik menggunakan Powder X-Ray Diffraction (PXRD). Hasil uji kelarutan menunjukkan bahwa α-mangostin murni tidak larut dalam media fosfat pH 7,4 (0 ppm), sedangkan DPA formula 1:1, 1:3, dan 1:5 menunjukkan kelarutan masing-masing sebesar 3,07 ± 0,90 ppm, 2,95 ± 0,01 ppm, dan 3,20 ± 0,02 ppm setelah 48 jam. Uji disolusi menunjukkan bahwa formula 1:1 memiliki pelepasan cepat dan stabil, mencapai 116% pada menit ke-20 dan bertahan di atas 110% hingga menit ke-120. Formula 1:3 menunjukkan pelepasan awal tinggi (91% pada menit ke-20), tapi menurun drastis menjadi 9% pada menit ke-60. Formula 1:5 memberikan pelepasan tertinggi (130% pada menit ke-60) dan tetap stabil di atas 110% hingga akhir waktu pengamatan. Uji stabilitas menunjukkan bahwa DPA formula 1:1, 1:3, dan 1:5 mengalami transformasi menuju bentuk amorf setelah 7 hari penyimpanan pada RH 0% dan RH 90%. Berdasarkan penelitian ini, dapat disimpulkan bahwa rasio PVP K-30 mempengaruhi kelarutan, profil disolusi, dan stabilitas fisik α-mangostin dalam sistem DPA. ----- α-Mangostin exhibits a wide range of biological activities; however, it’s extremely low water solubility limits its oral absorption. This study aimed to evaluate the physicochemical properties of an amorphous solid dispersion (ASD) system of αmangostin using polyvinylpyrrolidone (PVP) K-30 as a polymer, formulated via the solvent evaporation method. Three ASD formulations with α-mangostin:PVP K-30 ratios of 1:1, 1:3, and 1:5 were assessed for solubility, dissolution profile, and physical stability using Powder X-Ray Diffraction (PXRD). Solubility testing showed that pure α-mangostin was insoluble in phosphate buffer pH 7.4 (0 ppm), while the 1:1, 1:3, and 1:5 ASD formulations demonstrated solubility levels of 3.07 ± 0.90 ppm, 2.95 ± 0.01 ppm, and 3.20 ± 0.02 ppm, respectively, after 48 hours. Dissolution testing revealed that the 1:1 formulation exhibited rapid and stable release, reaching 116% at 20 minutes and maintaining above 110% up to 120 minutes. The 1:3 formulation showed a high initial release (91% at 20 minutes) but dropped drastically to 9% at 60 minutes. The 1:5 formulation showed the highest release (130% at 60 minutes) and remained stable above 110% until the end of the observation period. Stability testing indicated that all formulations transformed into an amorphous form after 7 days of storage under both 20% and 90% relative humidity (RH). Based on these results, it can be concluded that the PVP K-30 ratio significantly influences the solubility, dissolution profile, and physical stability of α-mangostin in the ASD system.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | α-mangostin, dispersi padat amorf, PVP K-30, kelarutan, disolusi. ----- α-mangostin, amorphous solid dispersion, PVP K-30, solubility, dissolution. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 04 Sep 2025 02:32 |
| Last Modified: | 04 Sep 2025 02:32 |
| URI: | http://repository.stfi.ac.id/id/eprint/2758 |
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