KEZIA OKTAVIANI SINAGA, - (2025) EFEK EKSTRAK DAN FRAKSI DAUN KIRINYUH (Chromoaena odorata L.) TERHADAP HISTOPATOLOGI JANTUNG, AORTA, DAN HATI PADA TIKUS WISTAR JANTAN YANG DIINDUKSI DIET TINGGI LEMAK. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Hiperlipidemia merupakan salah satu faktor risiko utama aterosklerosis yang dapat memicu penyakit kardiovaskular.Daun kirinyuh (Chromolaena odorata L.) diketahui mengandung senyawa bioaktif seperti flavonoid, tanin, dan terpenoid yang berpotensi menurunkan kadar lipid dan melindungi jaringan dari kerusakan oksidatif. Penelitian ini bertujuan untuk mengevaluasi efek pemberian ekstrak etanol dan fraksi daun kirinyuh terhadap gambaran histopatologi jantung, aorta, dan hati tikus Wistar jantan yang diinduksi diet tinggi lemak. Desain penelitian menggunakan metode eksperimental dengan rancangan acak lengkap, melibatkan kelompok kontrol normal, kontrol negatif, kontrol positif (simvastatin), ekstrak etanol daun kirinyuh, fraksi n-heksan, fraksi etil asetat, dan fraksi air. Perlakuan diberikan selama delapan minggu, diikuti pemeriksaan histopatologi menggunakan pewarnaan hematoksilin-eosin pada perbesaran mikroskop 400×. Parameter yang diamati meliputi aterosklerosis, sel busa (foam cells), steatosis, ballooning hepatosit, dan inflamasi. Hasil menunjukkan bahwa diet tinggi lemak memicu perubahan histopatologi signifikan pada semua organ yang diamati. Pemberian fraksi n-heksan menunjukkan tingkat kerusakan hati paling ringan dibanding perlakuan lain, meskipun belum mampu menyamai efektivitas simvastatin. Kesimpulannya, fraksi n-heksan daun kirinyuh memiliki potensi protektif terhadap kerusakan hati akibat hiperlipidemia dan berpeluang dikembangkan sebagai terapi herbal pendukung pada gangguan metabolisme lipid. ----- Hyperlipidemia is one of the main risk factorsfor atherosclerosis, which can trigger cardiovascular disease. Kirinyuh leaves (Chromolaena odorata L.) are known to contain bioactive compounds such as flavonoids, tannins, and terpenoids that have the potential to lower lipid levels and protect tissues from oxidative damage. This study aimed to evaluate the effects of ethanol extract and fractions of kirinyuh leaves on the histopathological features of the heart, aorta, and liver of male Wistar rats induced with a high-fat diet. The research design used an experimental method with a completely randomized design, involving a normal control group, a negative control group, a positive control group (simvastatin), ethanol extract of kirinyuh leaves, n-hexane fraction, ethyl acetate fraction, and aqueous fraction. Treatments were administered for eight weeks, followed by histopathological examination using hematoxylin–eosin staining under 400× microscope magnification. The parameters observed included atherosclerosis, foam cells, steatosis, hepatocyte ballooning, and inflammation. The results showed that a high-fat diet induced significant histopathological changes in all observed organs. Administration of the n-hexane fraction showed the mildest liver damage compared to other treatments, although it did not yet match the effectiveness of simvastatin. In conclusion, the nhexane fraction of kirinyuh leaves has protective potential against liver damage caused by hyperlipidemia and has the potential to be developed as a supportive herbal therapy for lipid metabolism disorders.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Chromolaena odorata, daun kirinyuh, hiperlipidemia, histopatologi, aterosklerosis, sel busa. ----- Chromolaena odorata, kirinyuh leaves, hyperlipidemia, histopathology, atherosclerosis, foam cells. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 01 Sep 2025 02:10 |
| Last Modified: | 01 Sep 2025 02:10 |
| URI: | http://repository.stfi.ac.id/id/eprint/2740 |
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