PENINGKATAN RENDEMEN SINTESIS TURUNAN BENZIL ETER DARI ALFA-MANGOSTIN MELALUI REAKSI ETERIFIKASI

IPAN RUSTANDI, - (2025) PENINGKATAN RENDEMEN SINTESIS TURUNAN BENZIL ETER DARI ALFA-MANGOSTIN MELALUI REAKSI ETERIFIKASI. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

α-Mangostin merupakan senyawa turunan xanton yang ditemukan pada kulit buah manggis (Garcinia mangostana L.) dan dikenal memiliki aktivitas farmakologis, termasuk sebagai antioksidan. Namun, penggunaannya dalam formulasi farmasi masih terbatas terkait dengan sifat fisikokimianya. Pada penelitian ini dilakukan derivatisasi α-mangostin menjadi benzil eter menggunakan katalis basa natrium tert-butoksida dan benzil klorida sebagai reagen. Reaksi dilakukan selama 24 jam, kemudian dilakukan pemurnian menggunakan kromatografi kolom. Keberhasilan derivatisasi dikonfirmasi melalui analisis KLT, spektrofotometri UV-Vis, dan FTIR. Spektrum UV-Vis menunjukkan pergeseran panjang gelombang dari 314 nm (standar) menjadi 256 nm (derivat), sedangkan FTIR menunjukkan hilangnya serapan gugus –OH pada 3419,75-3264,24 cm⁻¹ dan munculnya serapan khas gugus eter pada 1182,54-1004,54 cm⁻¹ , serta gugus benzil aromatik pada 3028,37 cm⁻¹. Hasil sintesis menunjukkan rendemen derivat sebesar 81,66%, meningkat signifikan dibandingkan penelitian sebelumnya yang hanya mencapai 2,5%. Uji aktivitas antioksidan menggunakan metode DPPH menunjukkan nilai IC₅₀ derivat sebesar 6,62 ppm, sedikit lebih kuat dibandingkan α-mangostin standar (6,96 ppm). Penelitian ini menunjukkan bahwa optimasi reaksi derivatisasi berhasil menghasilkan rendemen produk yang tinggi. ------ α-Mangostin is a xanthone derivative found in the rind of mangosteen fruit (Garcinia mangostana L.) and is known for its pharmacological activities, including antioxidant properties. However, its application in pharmaceutical formulations remains limited due to its physicochemical characteristics. In this study, α-mangostin was derivatized into benzyl ether using sodium tert-butoxide as a base catalyst and benzyl chloride as the reagent. The reaction was carried out for 24 hours, then purification was carried out using column chromatography. The success of the derivatization was confirmed through KLT analysis, UV-Vis spectrophotometry, and FTIR. The UV-Vis spectrum showed a wavelength shift from 314 nm (standard) to 256 nm (derivative), while FTIR showed a loss of –OH group uptake at 3419.75-3264.24 cm⁻¹ and the emergence of a typical ether group at 1182.54-1004.54 cm⁻¹, as well as an aromatic benzyl group at 3028.37 cm⁻¹. The synthesis results showed a derivative yield of 81.66%, a significant increase compared to the previous study which only reached 2.5%. Antioxidant activity tests using the DPPH method showed an IC₅₀ derivative value of 6.62 ppm, slightly stronger than standard α-mangostin (6.96 ppm). This study shows that the optimization of the derivatization reaction successfully results in high product yields.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Rendemen, derivatiasi, eterifikasi, benzil eter, antioksidan. ----- Yield, derivation, etherification, benzyl ether, antioxidants
Subjects:	Q Science > Q Science (General) Q Science > QD Chemistry
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	01 Sep 2025 01:57
Last Modified:	01 Sep 2025 01:57
URI:	http://repository.stfi.ac.id/id/eprint/2737

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