ICHSANI NUR ISLAMI, - (2025) OPTIMASI EKSTRAKSI HERBA SAMBILOTO (Andrographis paniculata) TERHADAP RENDEMEN EKSTRAK DAN KADAR ANDROGRAFOLID MENGGUNAKAN RESPONSE SURFACE METHODOLOGY (RSM). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Sambiloto (Andrographis paniculata (Burm. f.) Nees) dikenal memiliki berbagai aktivitas farmakologis, salah satunya berasal dari kandungan senyawa aktif andrografolid. Penelitian ini bertujuan untuk mengoptimalkan proses ekstraksi herba sambiloto terhadap rendemen dan kadar andrografolid menggunakan metode Response Surface Methodology (RSM). Simplisia diuji kualitasnya berdasarkan parameter Farmakope Herbal Indonesia dan dilakukan skrining fitokimia. Proses ekstraksi menggunakan metode refluks dengan pelarut etanol, memvariasikan suhu (50-70°C), waktu (60-120 menit), konsentrasi pelarut (70-96%), dan jumlah bahan (10-20 gram). Hasil menunjukkan bahwa variabel jumlah bahan berpengaruh signifikan terhadap rendemen (p < 0,05), sementara tidak ada variabel yang signifikan terhadap kadar andrografolid. Nilai rendemen tertinggi diperoleh sebesar 9,9%, dan kadar andrografolid tertinggi sebesar 46,75%. Model RSM untuk rendemen memiliki nilai R² sebesar 77,01%, sedangkan model untuk kadar andrografolid memiliki nilai R² yang rendah (57,11%) dengan R² adjusted dan predicted yang tidak memadai. Penelitian ini menunjukkan bahwa metode RSM dapat digunakan untuk optimasi rendemen ekstrak, namun perlu penyempurnaan model untuk kadar andrografolid. ----- Sambiloto (Andrographis paniculata (Burm. f.) Nees) is known to have various pharmacological activities, one of which comes from the content of andrographolid active compounds. This research aims to optimise the extraction process of sambiloto herbs towards the yield and andrografolid levels using the Response Surface Methodology (RSM). Simplisia's quality was tested based on the parameters of the Indonesian Herbal Pharmacopoeia and phytochemical screening was carried out. The extraction process uses the reflux method with ethanol solvent, varying temperature (50-70°C), time (60-120 minutes), solvent concentration (70- 96%), and amount of material (10-20 grams). The results show that the variable of the amount of ingredients has a significant effect on the yield (p < 0,05), while there is no significant variable on the level of andrographolids. The highest yield value was obtained at 9,9%, and the highest andrographolite level was 46.75%. The RSM model for yield has an R² value of 77,01%, while the model for andrographolid levels has a low R² value (57,11%) with an inadequate R² adjusted and predicted. This research shows that the RSM method can be used for extract yield optimisation, but the model refinement for andrographolid levels is needed.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Sambiloto, Andrografolid, Ekstraksi Refluks, RSM, Rendemen, Optimasi ------ Sambiloto, Androgrosolid, Reflux Extraction, RSM, Rendement, Optimisation |
| Subjects: | Q Science > QH Natural history > QH301 Biology R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 30 Aug 2025 03:52 |
| Last Modified: | 30 Aug 2025 03:52 |
| URI: | http://repository.stfi.ac.id/id/eprint/2736 |
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