HELLEN SULASSRI LIMBONG, - (2025) EVALUASI FISIK DISPERSI PADAT AMORF KURKUMIN DENGAN POLIMER POLYVINYL PYROLIDONE (PVP) K30 MENGGUNAKAN METODE SOLVENT EVAPORATION. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Kurkumin merupakan senyawa aktif utama dari rimpang Curcuma longa dengan berbagai aktivitas farmakologis, namun penggunaannya secara oral terbatas akibat kelarutan air yang sangat rendah sehingga membatasi bioavaibilitasnya. Salah satu strategi peningkatan kelarutan adalah pembentukan dispersi padat amorf menggunakan polimer hidrofilik untuk mengubah struktur kristalin menjadi amorf. Penelitian ini bertujuan mengevaluasi sifat fisik dispersi padat kurkumin dengan polyvinyl pyrrolidone (PVP) K30 terhadap kelarutan, profil disolusi, dan stabilitas fisik. Dispersi padat dibuat dengan metode solvent evaporation pada rasio kurkumin:PVP K30 sebesar 1:1, 1:3, dan 1:5, kemudian diuji kelarutan, disolusi dalam dapar fosfat pH 7,4, serta stabilitas fisik menggunakan PXRD pada kelembapan RH 20% dan RH 90% selama tujuh hari.Hasil menunjukkan kelarutan dispersi padat meningkat dibandingkan kurkumin murni (0 ppm), dengan nilai tertinggi pada formula 1:1 sebesar 11,079 ± 0,546 ppm, diikuti 1:3 sebesar 5,937 ± 0,220 ppm, dan 1:5 sebesar 2,002 ± 1,632 ppm. Profil disolusi formula 1:1 menunjukkan pelepasan stabil dengan persentase tertinggi sebesar 6,852%. Uji stabilitas menunjukkan formula 1:5 tetap stabil berbentuk amorf setelah tujuh hari penyimpanan. Berdasarkan penelitian ini dapat disimpulkan,penggunaan PVP K30 mampu meningkatkan kelarutan, memperbaiki profil disolusi, dan menjaga stabilitas fisik kurkumin melalui pembentukan bentuk amorf. ------ Curcumin is the main active compound derived from the rhizome of Curcuma longa with various pharmacological activities; however, its oral use is limited due to its very low water solubility, which consequently restricts its bioavailability. One strategy to improve its solubility is the preparation of amorphous solid dispersions using hydrophilic polymers to convert the crystalline structure into an amorphous form. This study aimed to evaluate the physicochemical properties of curcumin solid dispersions with polyvinyl pyrrolidone (PVP) K30 in relation to solubility, dissolution profile, and physical stability. Solid dispersions were prepared by the solvent evaporation method at curcumin:PVP K30 ratios of 1:1, 1:3, and 1:5, followed by solubility testing, dissolution testing in phosphate buffer pH 7.4, and physical stability testing using PXRD under relative humidity (RH) conditions of 20% and 90% for seven days.The results showed that the solubility of the solid dispersions increased compared to pure curcumin (0 ppm), with the highest value obtained for the 1:1 ratio (11.079 ± 0.546 ppm), followed by 1:3 (5.937 ± 0.220 ppm) and 1:5 (2.002 ± 1.632 ppm) after 48 hours. The dissolution profile of the 1:1 formula demonstrated stable release with the highest percentage of 6.852%. Stability testing revealed that the 1:5 formula remained stable in an amorphous state after seven days of storage.In conclusion, the use of PVP K30 effectively enhanced the solubility, improved the dissolution profile, and maintained the physical stability of curcumin through the formation of an amorphous solid dispersion.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | kurkumin, PVP K30, amorf, disolusi, stabilitas. ------ curcumin, PVP K30, Amorphous, Dissolution, Stability |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 30 Aug 2025 03:43 |
| Last Modified: | 30 Aug 2025 03:43 |
| URI: | http://repository.stfi.ac.id/id/eprint/2735 |
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