APRILIANI TRI AMBARWATI, - (2025) UJIAKTIVITASANTIDIABETESEKSTRAKDAUN KIRINYUH (Chromolaena odorata L.)PADA TIKUS JANTAN GALUR WISTAR DENGAN METODEINSULINSECRETAGOGUES. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Diabetes melitus merupakan penyakit metabolik kronis yang ditandai dengan peningkatan kadar glukosa darah akibat gangguan sekresi atau kerja insulin. Pengobatan diabetes berbasis obat sintetik sering menimbulkan efek samping dan resistensi, sehingga diperlukan alternatif pengobatan berbasis bahan alam. Tanaman kirinyuh (Chromolaena odorata L.) diketahui mengandung senyawa bioaktif seperti flavonoid, saponin, dan tanin yang berpotensi sebagai agen antidiabetes. Penelitian ini bertujuan untuk menguji aktivitas antidiabetes ekstrak etanol daun kirinyuh sebagai insulin-secretagogues pada tikus putih jantan galur Wistar yang diinduksi streptozotocin (STZ) dosis 40 mg/kgBB. Tikus dibagi menjadi enam kelompok, yaitu kelompok normal, kontrol negatif, kontrol positif (glibenklamid), serta tiga kelompok perlakuan yang diberikan ekstrak etanol daun kirinyuh dengan dosis masing-masing 150, 200, dan 250 mg/kgBB. Kadar glukosa darah diukur pada hari ke-0, hari ke-7 pasca induksi, serta hari ke-7, 14, dan 21 setelah perlakuan. Hasil menunjukkan bahwa ekstrak daun kirinyuh secara signifikan menurunkan kadar glukosa darah, dengan efektivitas tertinggi pada dosis 250 mg/kgBB yang mencapai penurunan sebesar 66,67%. Penurunan ini diduga melalui stimulasi sekresi insulin oleh sel β pankreas. Ekstrak daun kirinyuh berpotensi sebagai kandidat fitofarmaka untuk terapi diabetes melitus tipe 2. ----- Diabetes mellitus is a chronic metabolic disorder characterized by elevated blood glucose levels due to impaired insulin secretion or action. Synthetic drug-based treatments for diabetes often cause side effects and resistance, making natural product-based alternatives necessary. The kirinyuh plant (Chromolaena odorata L.) is known to contain bioactive compounds such as flavonoids, saponins, and tannins, which have potential as antidiabetic agents. This study aimed to evaluate the antidiabetic activity of ethanol extract of kirinyuh leaves as an insulin secretagogue in male Wistar rats induced with streptozotocin (STZ) at a dose of 40 mg/kgbw. The rats were divided into six groups: normal control, negative control, positive control (glibenclamide), and three treatment groups receiving ethanol extract of kirinyuh leaves at doses of 150, 200, and 250 mg/kgbw, respectively. Blood glucose levels were measured on day 0, day 7 post-induction, and on days 7, 14, and 21 after treatment. The results showed that kirinyuh leaf extract significantly reduced blood glucose levels, with the highest effectiveness observed at a dose of 250 mg/kgbw, achieving a reduction of 66.67%. This reduction is presumed to occur through stimulation of insulin secretion by pancreatic β-cells. Kirinyuh leaf extract shows potential as a phytopharmaceutical candidate for the treatment of type 2 diabetes mellitus.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Daun Kirinyuh (Chromolaena odorata L.), diabetes melitus, insulin-secretagogues, streptozotocin, kadar gula darah. ---- Kirinyuh leaves (Chromolaena odorata L.), diabetes mellitus, insulin-secretagogue, streptozotocin, blood sugar levels. |
| Subjects: | R Medicine > R Medicine (General) R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 29 Aug 2025 07:54 |
| Last Modified: | 29 Aug 2025 07:54 |
| URI: | http://repository.stfi.ac.id/id/eprint/2721 |
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