INTAN PERMATA SARI, - (2023) PENGARUH WAKTU PENYIMPANAN TERHADAP KADAR NANOCONFINED COAMORPHOUS (NCA) ETIL p-METOKSISINAMAT (EPMS) DARI RIMPANG KENCUR (Kaempferiae galanga L.). Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Nanoconfined coamorphous (NCA) merupakan suatu partikel dimana memuat active pharmaceutical ingredients (API) dan koformer ke dalam suatu mesopori. Etil p-metoksisinamat (EPMS) telah berhasil dibentuk NCA untuk meningkatkan kelarutan dan disolusinya. Untuk memastikan EPMS dalam bentuk NCA tidak mengalami kerusakan selama penyimpanan adalah dengan mengukur kadar EPMS tersebut. Tujuan penelitian ini adalah untuk mengetahui pengaruh waktu penyimpanan terhadap kadar EPMS dalam bentuk NCA. Metode yang digunakan adalah NCA EPMS disimpan dalam climatic chamber pada suhu 40°±2°C dan kelembaban 75%±5% selama 3 bulan. Sampel yang diuji adalah EPMS, amorf EPMS, NCA EPMS asam oksalat, NCA SE EPMS asam oksalat, NCA EPMS nikotinamida, NCA SE EPMS nikotinamida, dan NCA MQ EPMS nikotinamida. Pengukuran kadar EPMS dilakukan pada bulan ke-0, 1, 2, dan 3 menggunakan spektrofotometer UV-Vis. Berdasarkan hasil penelitian, selama 3 bulan kadar EPMS berbeda signifikan dengan amorf EPMS dan NCA EPMS. Kadar EPMS selama 3 bulan 111,985%-100,689%, amorf EPMS 6,102%-7,455%, NCA EPMS asam oksalat 4,579%-4,655%, NCA SE EPMS asam oksalat 6,476%-4,919%, NCA EPMS nikotinamida 5,622%-6,538%, NCA SE EPMS nikotinamida 3,147%-3,825%, dan NCA MQ EPMS nikotinamida 5,026%-5,131%. Berdasarkan penelitian ini, kesimpulan yang diperoleh adalah NCA dapat menstabilkan EPMS selama penyimpanan 3 bulan pada suhu 40°±2°C dan kelembaban 75%±5%. --- Nanoconfined coamorphous (NCA) contains active pharmaceutical ingredients (APIs) and coformers into a mesoporous. Ethyl p-methoxycinnamate (EPMS) has successfully formed NCA to improve its solubility and dissolution. In order to ensure that EPMS in the form of NCA is not damaged during storage, the EPMS values must be measured. This study aimed to determine the effect of storage time on EPMS levels in the form of NCA. The method used is NCA EPMS stored in a climatic chamber at a temperature of 40 ° ± 2 ° C and humidity of 75% ±5% for 3 months. The samples tested were EPMS, amorphous EPMS, NCA EPMS oxalic acid, NCA SE EPMS oxalic acid, NCA EPMS nicotinamide, NCA SE EPMS nicotinamide, and NCA MQ EPMS nicotinamide. Measurements of EPMS levels were performed at months 0, 1, 2, and 3 using a UV-Vis spectrophotometer. Based on the results of the study, for 3 months, EPMS levels were significantly different from amorphous EPMS and NCA EPMS. EPMS levels for 3 months 111.985%-100.689%, amorphous EPMS 6.102%-7.455%, NCA EPMS oxalic acid 4.579%-4.655%, NCA SE EPMS oxalic acid 6.476%-4.919%, NCA EPMS nicotinamide 5.622%-6.538%, NCA SE EPMS nicotinamide 3.147%-3.825%, and NCA MQ EPMS nicotinamide 5.026%-5.131%. Based on this study, the conclusion obtained is that NCA can stabilize EPMS during 3 months of storage at 40°±2°C and humidity of 75%±5%.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Etil p-metoksisinamat (EPMS), Nanoconfined Coamorphous (NCA), stabilitas, kadar. Ethyl p-methoxycinnamate (EPMS), Nanoconfined Coamorphous (NCA), stability, content. |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 21 Jun 2024 02:51 |
| Last Modified: | 21 Jun 2024 02:51 |
| URI: | http://repository.stfi.ac.id/id/eprint/271 |
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