FORMULASI DAN EVALUASI SEDIAAN TABLET ISOLAT BRAZILIN TANPA DAN DENGAN PEMBENTUKAN DISPERSI PADAT

NADIA GANIA SYIFA, - (2025) FORMULASI DAN EVALUASI SEDIAAN TABLET ISOLAT BRAZILIN TANPA DAN DENGAN PEMBENTUKAN DISPERSI PADAT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Brazilin, senyawa aktif utama dalam kayu secang (Caesalpinia sappan), memiliki aktivitas farmakologis yang potensial, namun kelarutannya yang rendah dalam air membatasi efektivitas terapinya. Penelitian ini bertujuan untuk memformulasi dan mengevaluasi tablet isolat brazilin tanpa dan dengan pembentukan dispersi padat sebagai upaya meningkatkan kelarutan dan disolusi. Dispersi padat dibuat dalam bentuk amorf menggunakan polivinilpirolidon (PVP K-30) dengan rasio 1:1 terhadap brazilin melalui metode solvent evaporation. Setelah dikeringkan, dispersi padat digunakan dalam formulasi tablet melalui metode kempa langsung bersama eksipien seperti Avicel PH 102, Primogel, magnesium stearat, dan Aerosil. Evaluasi meliputi uji sifat serbuk (laju alir, sudut diam, kompresibilitas, distribusi ukuran partikel) dan sifat tablet (keseragaman bobot, ukuran, kekerasan, kerapuhan, waktu hancur, profil disolusi, dan kadar zat aktif). Hasil menunjukkan bahwa tablet dengan dispersi padat (F5 dan F6) memiliki waktu hancur dan uji disolusi yang lebih cepat dibanding tablet tanpa dispersi. Formula F6 telah mencapai pelepasan sebesar 98,22% pada menit ke-60 dan menunjukkan waktu hancur tercepat yaitu 42 detik. Disimpulkan bahwa pembentukan dispersi padat amorf dengan PVP K-30 efektif dalam meningkatkan kecepatan disolusi brazilin dalam sediaan tablet. ------ Brazilin, the main active compound in sappan wood (Caesalpinia sappan), possesses significant pharmacological activity, but its poor water solubility limits its therapeutic effectiveness. This study aimed to formulate and evaluate brazilin tablets, both without and with solid dispersion formation, as an approach to improve solubility and dissolution. An amorphous solid dispersion was prepared using polyvinylpyrrolidone (PVP K-30) at a 1:1 ratio with brazilin through the solvent evaporation method. After drying, the solid dispersion was used in tablet formulation via direct compression together with excipients such as Avicel PH 102, Primogel, magnesium stearate, and Aerosil. Evaluations included powder properties (flow rate, angle of repose, compressibility, particle size distribution) and tablet properties (weight and size uniformity, hardness, friability, disintegration time, dissolution profile, and content assay). The results showed that tablets containing solid dispersion (F5 and F6) had faster disintegration and dissolution compared to tablets without dispersion. Formula F6 achieved 98.22% drug release at 60 minutes and had the fastest disintegration time of 42 seconds. It can be concluded that the formation of an amorphous solid dispersion with PVP K-30 effectively improves the dissolution rate of brazilin in tablet dosage form.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Brazilin, tablet, dispersi padat, PVP K-30, disolusi. ---- Brazilin, tablet, solid dispersion, PVP K-30, dissolution
Subjects:	R Medicine > R Medicine (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	28 Aug 2025 03:06
Last Modified:	28 Aug 2025 06:33
URI:	http://repository.stfi.ac.id/id/eprint/2709

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