IRMA ERIKA HERAWATI, - and RONY LESMANA, - and JUTTI LEVITA, - and ANAS SUBARNAS, - (2022) PREDICTION OF ANTICANCER ACTIVITY OF RICIN-A THROUGH AUTOPHAGY PATHWAY USING MOLECULAR DOCKING ON BECLIN-1, LC3, AND p62. Jurnal Ilmiah Farmako Bahari, 13 (1). pp. 22-30.
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Abstract
Autophagy is an adaptation process carried out as a defense in cellular responses, such as nutritional deficiencies or other metabolic stresses. The mechanism of autophagy is regulated by proteins called Autophagy Related Genes (ATG). Autophagy has also been widely associated with various diseases in humans, such as cancer and other degenerative diseases. Ricin is a toxic protein derived from the castor bean, Ricinus communisL., that has been explored for its potential as an anticancer via the activation of the caspases signaling pathway (apoptosis). This study was conducted to determine the binding mode that occurs between ricin-A and proteins that play a role in each step of the autophagy process (Beclin-1, LC3 or Light Chain 3, and p62/Sequistrosome1). The protein-protein docking simulation was employed by using the ClusPro online server (https://cluspro.org). The results showed that ricin-A could bind to Beclin-1. LC3, and p62 by building hydrogen bonds with good affinity. We conclude that ricin-A plays an important role to modulate the autophagy process, thus, could be further developed as an anticancer phytopharmaceutical.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | autophagy,autophagy-related genes,Beclin-1,ricin-A,Ricinus communisL |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Lembaga Penelitian dan Pengabdian Masyarakat > Publikasi Penelitian |
| Depositing User: | Irma Erika - - |
| Date Deposited: | 03 Jul 2025 05:15 |
| Last Modified: | 03 Jul 2025 05:15 |
| URI: | http://repository.stfi.ac.id/id/eprint/2599 |
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