Appraisal of Jatropha curcas leaf characteristic as a natural anti-vaginal candidiasis.

SRI AGUNG FITRI KUSUMA, - and IRMA ERIKA HERAWATI, - and CICIH DARNIASIH, - (2020) Appraisal of Jatropha curcas leaf characteristic as a natural anti-vaginal candidiasis. Drug Invention Today, 13 (7). ISSN 0975-7619

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Abstract

Aim: The aim of the study was to appraise the antifungal properties of Jatropha curcas leaf ethanolic extract against Candida albicans as the most causative pathogen of vaginal candidiasis. Materials and Methods: The dried J. curcas leaf was extracted in 70% ethanol using a maceration method. The extract was then analyzed using a standard method to detect the antifungal phytochemical constituent. The antifungal potential of the extract was investigated using the agar diffusion method. To appraise the antifungal properties, the minimum inhibitory concentration (MIC) value of the extract was determined using the microdilution method. The MIC result then subcultured on the surface of agar media to obtain the minimum fungicidal concentration (MFC). As an anti-vaginal candidiasis candidate, the antifungal activity of the extract was compared to ketoconazole using the agar diffusion method. Results and Discussion: The extraction of J. curcas leaf yielded a thick extract in a weight of 228.92 g. The ethanolic extract of J. curcas leaves contained phytochemical compounds as follows: Tannins, flavonoids, saponins, and steroids. The extract exhibited a dose-dependent antifungal activity against C. albicans. The MIC value of the extract exhibited the same range of concentration as the MFC value, i.e., 0.1 < MIC < 0.2 mg/mL. The comparative test value of extracts against ketoconazole is 1:96,078.78. Conclusion: We conclude that the antifungal characteristics of J. curcas leaf ethanolic extract are a fungicidal agent with a strong antifungal activity against C. albicans.

Item Type:	Article
Uncontrolled Keywords:	PHYTOCHEMICALS; CANDIDIASIS; JATROPHA; VULVOVAGINAL candidiasis; CANDIDEMIA; ANTIFUNGAL agents; CANDIDA albicans; KETOCONAZOLE
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Lembaga Penelitian dan Pengabdian Masyarakat > Publikasi Penelitian
Depositing User:	Irma Erika - -
Date Deposited:	03 Jul 2025 05:06
Last Modified:	03 Jul 2025 05:06
URI:	http://repository.stfi.ac.id/id/eprint/2577

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