ALYAA DIZA PERTIWI, - (2023) PENETAPAN AKTIVITAS ANTIOKSIDAN DAN KADAR TOTAL FLAVONOID DARI EKSTRAK HERBA GINSENG JAWA (Talinum paniculatum Gaertn) DENGAN METODE SOXHLET DAN PERBANDINGAN VARIASI KONSENTRASI ETANOL. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Herba ginseng jawa (Talinum paniculatum Gaertn) merupakan tanaman yang memiliki aktivitas antioksidan yang dapat melindungi tubuh dari radikal bebas. Penelitian ini bertujuan untuk mengetahui aktivitas antioksidan dan kadar total flavonoid herba ginseng jawa yang diekstrak dengan berbagai variasi konsentrasi etanol (50%, 70% dan 96%). Herba ginseng jawa diekstraksi dengan metode soxhlet. Aktivitas antioksidan diukur dengan metode DPPH (1,1-difenil-2 pikrilhidrazil) dan penetapan kadar total flavonoid dilakukan secara spektrofotometri UV – Vis dengan metode kolorimetri. Hasil penelitian menunjukkan bahwa rendemen tertinggi diperoleh dari ekstrak etanol 50% yaitu sebesar 20,05%; ekstrak etanol 70% sebesar 18,63% dan ekstrak etanol 96% sebesar 15,5%. Aktivitas antioksidan tertinggi herba ginseng jawa diperoleh dari ekstrak etanol 70% yaitu nilai IC50 sebesar 20 ppm; ekstrak etanol 50% yaitu nilai IC50 sebesar 39,12 ppm dan ekstrak etanol 96% yaitu nilai IC50 sebesar 20,9 ppm. Kadar total flavonoid tertinggi pada ekstrak etanol 50% dengan kadar 1,674 g QE/100g; ekstrak etanol 70% sebesar 1,441 g QE/100g dan 96% sebesar 1,143 g QE/100g Kromatografi Lapis Tipis diperoleh dugaan warna biru; kuning; hijau dan diperoleh nilai Rf dengan range 0,24 – 0,98. Kesimpulannya, ekstrak etanol 50% memiliki rendemen tertinggi, ekstrak etanol 70% memiliki aktivitas antioksidan tertinggi dan ekstrak 50% memiliki kadar total flavonoid tertinggi. --- Javanese ginseng herb (Talinum paniculatum Gaertn) is a plant that has antioxidant activity that can protect the body from free radicals. This study aims to determine the antioxidant activity and total flavonoid content of Javanese ginseng herb extracted with various concentrations of ethanol (50%, 70% and 96%). Javanese ginseng herb is extracted by the soxhlet method. Antioxidant activity was measured by the DPPH (1,1-diphenyl-2-pikrylhidrazyl) method and the determination of total flavonoid levels was carried out by UV – Vis spectrophotometry by colorimetric method. The results showed that the highest yield was obtained from 50% ethanol extract, namely 20.05%; 70% ethanol extract by 18.63% and 96% ethanol extract by 15.5%. The highest antioxidant activity of Javanese ginseng herb was obtained from 70% ethanol extract, namely the IC50 value of 20 ppm; 50% ethanol extract has an IC50 value of 39.12 ppm and 96% ethanol extract has an IC50 value of 20.9 ppm. The highest total flavonoid content was found in 50% ethanol extract with a content of 1.674 g QE/100g; 70% ethanol extract of 1.441 g QE/100g and 96% of 1.143 g QE/100g Thin Layer Chromatography obtained an alleged blue color; yellow; green and obtained Rf values with a range of 0.24 – 0.98. In conclusion, 50% ethanol extract had the highest yield, 70% ethanol extract had the highest antioxidant activity and 50% extract had the highest total flavonoid content.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Herba ginseng jawa, antioksidan, flavonoid Javanese ginseng herb, antioxidant, flavonoid |
| Subjects: | R Medicine > RV Botanic, Thomsonian, and eclectic medicine |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 20 Jun 2024 01:47 |
| Last Modified: | 20 Jun 2024 01:47 |
| URI: | http://repository.stfi.ac.id/id/eprint/240 |
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