RIZKA ZAIDAH MAWLIDIYAH, - (2023) PENGARUH PEMBERIAN EKSTRAK ETANOL DAUN CINCAU HITAM (Mesona palustris BL) TERHADAP PROFIL LIPID TIKUS PUTIH JANTAN WISTAR (Rattus norvegicus) HIPERLIPIDEMIA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Hiperlipidemia adalah kondisi dimana konsentrasi lipid dalam tubuh meningkat, yang ditandai dengan peningkatan kadar kolesterol, trigliserida, Low Density Lipoprotein (LDL), dan menurunnya kadar High Density Lipoprotein (HDL). Daun cincau hitam (Mesona palustris BL) merupakan salah satu bagian tanaman yang memiliki potensi antihiperlipidemia. Tujuan dilakukannya penelitian ini untuk mengetahui efek dari ekstrak etanol daun cincau hitam terhadap penurunan kadar kolesterol, trigliserida, dan LDL, serta kenaikan kadar HDL pada tikus putih jantan wistar (Rattus norvegicus) hiperlipidemia. Ekstraksi daun cincau hitam menggunakan etanol 96%. Hewan uji terbagi menjadi enam kelompok, yaitu kontrol negatif, positif, pembanding simvastasin dosis 0,9 mg/Kg BB, ekstrak etanol daun cincau hitam dosis 200 mg/Kg BB, 400 mg/Kg BB, dan 600 mg/Kg BB. Semua kelompok hewan uji diinduksi dengan pakan kaya lemak, propylthiouracil (PTU) 12,5 mg/Kg BB, kolesterol murni 200 mg/Kg BB, dan asam kolat 75 mg/Kg BB selama 21 hari. Hasil menunjukkan bahwa pemberian ekstrak etanol daun cincau hitam selama 28 hari memberikan pengaruh yang signifikan dalam menurunkan kadar kolesterol, trigliserida, LDL, serta menaikkan kadar HDL pada kelompok dosis ekstrak etanol daun cincau hitam 400 mg/Kg BB. --- Hyperlipidemia is a condition where the concentration of lipids in the body increases, characterized by elevated levels of cholesterol, triglycerides, Low Density Lipoprotein (LDL), and a decrease in High-Density Lipoprotein (HDL) levels. Black cincau leaves (Mesona palustris BL) are one of the plant parts that have potential anti-hyperlipidemia properties. The aim of this research is to determine the effects of ethanol extract from black cincau leaves on reducing cholesterol, triglyceride, and LDL levels, as well as increasing HDL levels in hyperlipidemic male Wistar rats (Rattus norvegicus). The extraction of black cincau leaves was performed using 96% ethanol. The test animals were divided into six groups: negative control, positive control, simvastatin comparator at a dose of 0.9 mg/kg body weight, ethanol extract of black cincau leaves at doses of 200 mg/kg body weight, 400 mg/kg body weight, and 600 mg/kg body weight. All test animal groups were induced with high-fat diet, propylthiouracil (PTU) at 12.5 mg/kg body weight, pure cholesterol at 200 mg/kg body weight, and cholic acid at 75 mg/kg body weight for 21 days. The results showed that administering ethanol extract of black cincau leaves for 28 days significantly lowered cholesterol, triglyceride, LDL levels, and increased HDL levels in the group receiving a dose of 400 mg/kg body weight of the ethanol extract of black cincau leaves.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Daun cincau hitam (Mesona palustris BL), Hiperlipidemia, Profil lipid, Simvastatin. Black cincau leaves (Mesona palustris BL), Hyperlipidemia, Lipid profile, Simvastatin. |
| Subjects: | R Medicine > RM Therapeutics. Pharmacology |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 19 Jun 2024 07:05 |
| Last Modified: | 19 Jun 2024 07:05 |
| URI: | http://repository.stfi.ac.id/id/eprint/231 |
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