JULISTIAN DARMAWANSYAH, - (2023) PENETAPAN KADAR MANGOSTIN TERLARUT DALAM COCONUT OIL, SUNFLOWER OIL, CASTOR OIL, ALMOND OIL, PEG 400 MENGGUNAKAN SPEKTROFOTOMETRI UVVIS. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Mangostin merupakan sebuah senyawa yang berasal dari tumbuhan manggis (Garcinia mangostana L.), sudah diakui mempunyai potensi sebagai agen terapeutik dengan manfaat yang bermacam-macam seperti, antioksidan, antiinflamasi, antialergi, antijamur, antibakteri, antiparasit, antiobesitas, antidiabetes, dan berfungsi dalam pengobatan kanker hepatoseluler serta kanker payudara. Dalam konteks pengembangan obat-obatan, penting untuk memahami kelarutan senyawa seperti mangostin dalam berbagai pelarut guna merancang formulasi yang tepat, meningkatkan bioavailabilitas, dan efektivitasnya dalam pengobatan. Riset ini bertujuan untuk mengukur kadar terlarut mangostin dalam beberapa pelarut seperti Coconut Oil, Sunflower Oil, Castor Oil, Almond Oil, dan PEG 400, menggunakan metode spektrofotometri UV-Vis. Hasil penelitian menunjukkan bahwa kelarutan mangostin dalam Castor Oil adalah 309,8123ppm±131,265, dalam Coconut Oil adalah 394,2006ppm±0,11864, dalam Sunflower Oil adalah 380,3236ppm±0,24967, dalam Almond Oil adalah 319,8544ppm±0,25224, dan dalam PEG 400 adalah 632,7999ppm±2,91142. Dari hasil tersebut, dapat disimpulkan bahwa mangostin memiliki kelarutan yang sangat sukar larut dalam semua pelarut yang digunakan dalam riset ini. --- Mangostin, a compound derived from the mangosteen plant (Garcinia mangostana L.), has been recognized as a potential therapeutic agent with various benefits such as antioxidant, anti-inflammatory, antiallergic, antifungal, antibacterial, antiparasitic, antiobesity, antidiabetic, and functions in the treatment of hepatocellular cancer and breast cancer. In the context of drug development, it is important to understand the solubility of compounds such as mangostin in various solvents in order to design appropriate formulations, improve their bioavailability and effectiveness in treatment. This research aims to measure the soluble content of mangostin in several solvents such as Coconut Oil, Sunflower Oil, Castor Oil, Almond Oil, and PEG 400, using UV-Vis spectrophotometric method. The results showed that the solubility of mangostin in Castor Oil was 309.8123ppm±131.265, in Coconut Oil was 394.2006ppm±0.11864, in Sunflower Oil was 380.3236ppm±0.24967, in Almond Oil was 319.8544ppm±0.25224, and in PEG 400 was 632,7999ppm±2.91142. From these results, it can be concluded that mangostin has a very poor solubility in all solvents used in this research.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Mangostin, Kadar Terlarut, Coconut Oil, Sunflower Oil, Castor Oil, Almond Oil, PEG 400, Spektrofotometri UV-Vis. Mangostin, Dissolved Content, Coconut Oil, Sunflower Oil, Castor Oil, Almond Oil, PEG 400, UV-Vis Spectrophotometry |
| Subjects: | Q Science > QD Chemistry R Medicine > RS Pharmacy and materia medica |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 15 Jun 2024 03:03 |
| Last Modified: | 26 Jun 2024 01:25 |
| URI: | http://repository.stfi.ac.id/id/eprint/223 |
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