UJI SITOTOKSIK EKSTRAK HERBA GINSENG JAWA (Talinum paniculatum Gaertn) TERHADAP KEPOLARAN PELARUT

ASSYIFA NOOR LUTHFIAH, - (2023) UJI SITOTOKSIK EKSTRAK HERBA GINSENG JAWA (Talinum paniculatum Gaertn) TERHADAP KEPOLARAN PELARUT. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Tanaman ginseng telah meraih pengakuan yang luas di berbagai negara terutama di Cina, sebagai ramuan tradisional yang efektif dalam merawat berbagai penyakit. Daun ginseng Jawa diketahui memiliki potensi untuk meningkatkan produksi Air Susu Ibu (ASI), meningkatkan nafsu makan, sebagai obat bisul dan afrodisiak (obat kuat). Penelitian ini difokuskan pada uji toksisitas akut ekstrak herba ginseng Jawa terhadap larva udang Artemia salina Leach menggunakan metode Brine Shrimp Lethality Test (BSLT). Metode BSLT dipilih karena telah banyak digunakan sebagai pra-skrining senyawa aktif dalam ekstrak tumbuhan. Metode ini dianggap sederhana, cepat, murah, mudah dilakukan, dan hasil yang representatif. Tujuan dari penelitian ini adalah untuk menilai tingkat keamanan penggunaan ekstrak herba ginseng Jawa serta mengidentifikasi potensi aktivitas senyawa yang terkandung dalam ekstrak herba ginseng Jawa. Hasil penelitian menunjukkan bahwa ketiga ekstrak herba ginseng Jawa memiliki nilai LC50 (konsentrasi mematikan 50%) yang berbeda, yaitu 30,153 µg/mL untuk ekstrak etanol 96%, 35,657 µg/mL untuk ekstrak etanol 70%, dan 44,398 µg/mL untuk ekstrak etanol 50%. Dapat disimpulkan bahwa ekstrak herba ginseng Jawa memiliki potensi sitotoksik terhadap larva Artemia salina Leach, yang menunjukkan potensi penggunaan sebagai agen antikanker. --- The ginseng plant has gained wide recognition in various countries, especially in China, as an effective traditional herb in treating various ailments. Javanese ginseng leaves are known to have the potential to increase breast milk production, increase appetite, as a medicine for ulcers and aphrodisiac (strong medicine). This study focused on the acute toxicity test of Javanese ginseng herb extract against Artemia salina Leach shrimp larvae using the Brine Shrimp Lethality Test (BSLT) method. The BSLT method was chosen because it has been widely used as a prescreening of active compounds in plant extracts. This method is considered simple, fast, cheap, easy to perform, and representative results. The purpose of this study was to assess the safety level of the use of Javanese ginseng herb extracts and identify the potential activity of compounds contained in Javanese ginseng herb extracts. The results showed that the three extracts of Javanese ginseng herb had different LC50 (50% lethal concentration) values, namely 30.153 µg/mL for 96% ethanol extract, 35.657 µg/mL for 70% ethanol extract, and 44.398 µg/mL for 50% ethanol extract. It can be concluded that Javanese ginseng herb extract has cytotoxic potential against Artemia salina Leach larvae, which indicates its potential use as an anticancer agent.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Brine Shrimp Lethality Test (BSLT), ginseng Jawa, toksisitas akut. Brine Shrimp Lethality Test (BSLT), Javanese ginseng, acute toxicity.
Subjects:	R Medicine > RV Botanic, Thomsonian, and eclectic medicine
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	14 Jun 2024 06:37
Last Modified:	26 Jun 2024 01:31
URI:	http://repository.stfi.ac.id/id/eprint/208

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