UJI KELARUTAN KURKUMIN DI DALAM BERBAGAI KUALITAS MINYAK KELAPA

DIMAS AGUNG SURYA RAMADHAN, - (2023) UJI KELARUTAN KURKUMIN DI DALAM BERBAGAI KUALITAS MINYAK KELAPA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Kurkumin merupakan senyawa kimia murni yang diambil dari tanaman kunyit (Curcumae longa). Kurkumin bermanfaat sebagai antiinflamasi, anti oksidan, imunitas tubuh dan lain-lain. Kurkumin dapat dibuat dalam berbagai bentuk sediaan farmasi yang berbasis minyak kelapa sehingga dapat mengetahui kelarutan kurkumin dalam minyak kelapa sangatlah penting. Penelitian ini bertujuan untuk menentukan kadar kurkumin terlarut dalam berbagai minyak kelapa sawit yang ada di pasaran. Metode penentuan kadar menggunakan analisis spektrofotometri UV-Vis dengan prosedur yang meliputi penentuan panjang gelombang maksimum, pembuatan kurva baku, dan penetapan kadar terlarut. Hasil penelitian mencakup panjang gelombang maksimum, pembuatan kurva baku, dan hasil penentuan kadar terlarut dalam sampel-sampel minyak kelapa sawit. Panjang gelombang maksimum yang diperoleh dalam penelitian ini adalah 421 nm dalam metanol dan 421,8 nm dalam kloroform. Pembuatan kurva baku dilakukan dengan menggunakan standar kurkumin dalam rentang konsentrasi yang diketahui. Persamaan regresi yang diperoleh adalah y = 0,175x - 0,0087, dengan koefisien korelasi (R2) sebesar 0,9886. Hasil penentuan kadar terlarut kurkumin dalam sampel minyak kelapa sawit menunjukkan variabilitas dalam konsentrasi. Dari 5 jenis sample minyak kelapa yang dapat melarutkan kurkumin paling tinggi adalah sample 5 (VCO) dengan kosentrasi kurkumin terlarut 17,38 ± 0,11 ppm. Secara keseluruhan kelarutan kurkumin dalam minyak kelapa termasuk ke dalam kategori sukar larut. Berdasarkan hasil penelitian ini, dapat disimpulkan bahwa minyak kelapa sawit yang ada di pasaran memiliki kadar kurkumin terlarut yang bervariasi. Metode analisis spektrofotometri UV-Vis dengan pembuatan kurva kalibrasi menunjukkan ketepatan dan keandalan dalam penentuan kadar kurkumin terlarut dalam sampel minyak kelapa sawit. --- Curcumin is a pure chemical compound extracted from the turmeric plant ed(Curcuma longa). Curcumin is useful as an anti-inflammatory, antioxidant, body immunity and others. Curcumin can be made in various pharmaceutical dosage forms based on coconut oil so that knowing the solubility of curcumin in coconut oil is very important. This study aims to determine the soluble curcumin content in various palm oil products available in the market. The method used for determining the content involved UV-Vis spectroscopy analysis, which includes determining the maximum wavelength, creating a calibration curve, and quantifying the soluble curcumin content. The research results include the maximum wavelength, the calibration curve, and the quantified soluble curcumin content in the palm oil samples. The maximum wavelength obtained in this study was 421 nm in methanol and 421.8 nm in chloroform. The calibration curve was constructed using known concentrations of curcumin standards. The regression equation obtained was y = 0.175x - 0.0087, with a correlation coefficient (R2) of 0.9886. The results of determining the soluble curcumin content in the palm oil samples showed variability in the concentrations. Of the 5 types of coconut oil samples that could dissolve curcumin the highest was sample 5 (VCO) with a dissolved curcumin concentration of 17.38 ± 0.11 ppm. Overall the solubility of curcumin in coconut oil is in the category of poorly soluble. From this study, it can be concluded that palm oil products available in the market have varying levels of soluble curcumin content. The UV-Vis spectroscopy analysis method, combined with the creation of a calibration curve, demonstrated accuracy and reliability in determining the soluble curcumin content in the palm oil samples.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Kurkuminoid, kelarutan, spektrofotometer uv-vis, minyak kelapa sawit. Curcuminoids, solubility, spectrophotometer uv -vis, palm oil
Subjects:	Q Science > QD Chemistry
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	07 Jun 2024 07:23
Last Modified:	07 Jun 2024 07:23
URI:	http://repository.stfi.ac.id/id/eprint/189

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