STUDI INKOMPATIBILITAS ISOLAT MANGOSTIN TERHADAP BAHAN YANG BERFUNGSI SEBAGAI PENGIKAT PADA SEDIAAN SOLID

ANDIKA BAYU SAPUTRA, - (2024) STUDI INKOMPATIBILITAS ISOLAT MANGOSTIN TERHADAP BAHAN YANG BERFUNGSI SEBAGAI PENGIKAT PADA SEDIAAN SOLID. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Studi inkompatibilitas antara isolat mangostin dengan eksipien mempunyai peranan penting dalam pengembangan suatu formula obat. Hal tersebut dikarenakan interaksi antara isolat mangostin dengan eksipien dapat mempengaruhi stabilitas, sifat fisikokimia, keamanan, dan efikasi terapeutik dari obat. Penelitian ini bertujuan untuk mengevaluasi inkompatibilitas isolat mangostin terhadap tiga bahan pengikat, yaitu PVP K-30, PEG 6000, dan starch, serta mengidentifikasi pengaruhnya terhadap stabilitas isolat mangostin. Metode penelitian yang digunakan untuk mendeteksi inkompatibilitas, seperti High Perfomance Liquid Cromatography (HPLC), X-Ray Diffraction (XRD) dan differential scanning calorimetry (DSC). Berdasarkan analisis sifat termal, mangostin dan eksipien berpotensi mengalami interaksi karena mangostin tidak bisa mempertahankan titik leburnya pada semua campuran. Berdasarkan analisis kristalinitas, mangostin dengan PVP K30, mangostin dengan PEG 6000 serta Mangostin dengan starch berpotensi mengalami interaksi yang ditandai dengan pola difraktogram yang mengalami pergeseran. Berdasarkan analisis kadar mangostin dalam campuran, mangostin berpotensi mengalami interaksi dengan PVP K30 dan PEG 6000. Mangostin mengalami penurunan kadar sebesar 11,98% dengan PVP K30. Mangostin mengalami penurunan kadar sebesar 19,23% dengan PEG 6000. Hasil penelitian menunjukan bahwa analisis termal cukup efektif dalam mendeteksi inkompatibilitas dan menunjukkan eksipien bahan pengikat tidak meningkatkan nilai LOD, tetapi dapat meningkatkan kristalinitas dan titik leleh isolat mangostin berdasarkan hasil XRD dan DSC, serta bahan pengikat juga dapat menurunkan kadar isolat mangostin, sehingga dapat disimpulkan bahwa bahan pengikat ada indikasi terjadinya inkompatibilitas dengan isolat mangostin. ---- Incompatibility studies between mangostin isolates and excipients have an important role in developing a drug formula. This is because the interaction between mangostin isolate and excipients can affect the stability, physicochemical properties, safety and therapeutic efficacy of the drug. This study aims to evaluate the incompatibility of mangostin isolate with three binders, namely PVP K-30, PEG 6000, and starch, and identify its effect on the stability of mangostin isolate. Research methods used to detect incompatibility include High Performance Liquid Chromatography (HPLC), X-Ray Diffraction (XRD) and differential scanning calorimetry (DSC). Based on the analysis of thermal properties, mangostin and excipients have the potential to experience interactions because mangostin cannot maintain its melting point in all binary mixtures. Based on crystallinity analysis, mangostin with PVP K30, mangostin with PEG 6000 and mangostin with starch have the potential to experience interactions characterized by diffractogram patterns that experience shifts and disappearance of peaks in the binary mixture diffractogram. Based on analysis of mangostin levels in the mixture, mangostin has the potential to interact with PVP K30 and PEG 6000. Mangostin levels decreased by 11,98% with PVP K30. Mangostin levels decreased by 19,23% with PEG 6000. The research results showed that thermal analysis was quite effective in detecting incompatibility and showed that the binder excipient did not increase the LOD value, but could increase the crystallinity and melting point of mangostin isolate based on the XRD and DSC results, as well as the binder can also reduce the levels of mangostin isolate, so it can be concluded that the binder has indications of incompatibility with mangostin isolate.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Mangostin, Inkompatibilitas, PVP K30, PEG 6000, Starch, HPLC, XRD, DSC. ---- Mangostine, Incompatibility,PVP K30, PEG 6000,Starch, HPLC, XRD, DSC
Subjects:	Q Science > Q Science (General) R Medicine > RS Pharmacy and materia medica
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	04 Nov 2024 03:13
Last Modified:	04 Nov 2024 03:13
URI:	http://repository.stfi.ac.id/id/eprint/1463

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