ZAKIATUL MAISAH, - (2020) UJI EFEK ANTIGLAUKOMA KOMBINASI EKSTRAK BUAH DELIMA (Punica granatum L.) DAN SERBUK TELUR KEONG MAS (Pomacea canaliculata) PADA MODEL TIKUS GLAUKOMA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
![[img]](http://repository.stfi.ac.id/style/images/fileicons/text.png) |
Text
S_PSSF_A162033_Title.pdf Download (1MB) |
|
Text
S_PSSF_A162033_Chapter1.pdf Restricted to Repository staff only Download (16kB) |
|
Text
S_PSSF_A162033_Chapter2.pdf Restricted to Repository staff only Download (505kB) |
|
Text
S_PSSF_A162033_Chapter3.pdf Restricted to Repository staff only Download (25kB) |
|
Text
S_PSSF_A162033_Chapter4.pdf Restricted to Repository staff only Download (272kB) |
|
Text
S_PSSF_A162033_Chapter5.pdf Restricted to Repository staff only Download (6kB) |
|
Text
S_PSSF_A162033_Appendix.pdf Restricted to Repository staff only Download (859kB) |
Abstract
Glaukoma merupakan gangguan pada mata ditandai dengan peningkatan tekanan intraokular yang dapat menyebabkan kerusakan saraf optik progresif dan irreversibel. Buah Delima (Punica granatum L.) dan telur keong mas (Pomea canaliculata) telah diketahui mengandung flavonoid dan pigmen karoten yang berpotensi menurunkan tekanan intraokular. Penelitian ini dilakukan untuk mengetahui adanya penurunan tekanan intraokular (TIO) pada model tikus glaukoma dengan kombinasi ekstrak buah delima (Punica granatum L.) dan serbuk telur keong mas (Pomea canaliculata). Buah delima (Punica granatum L.) yang telah dikeringkan diekstraksi dengan etanol 70% selama 5 hari. Ekstrak cair kemudian dievaporasi hingga terbentuk ekstrak kental. Telur keong mas diperas dan dikeringkan cairannya dalam oven suhu 50oC selama 24 jam hingga terbentuk serbuk. Penelitian ini menggunakan 6 kelompok uji yang terdiri dari kontrol normal, kontrol negatif, kontrol positif, kelompok ekstrak buah delima, kelompok serbuk telur keong mas dan kelompok kombinasi. Glaukoma diinduksi menggunakan prednisolone asetat 1% dan pembanding positif asetazolamid. Pengukuran tekanan bola mata menggunakan tonometer schiotz. Hasil menunjukkan ekstrak buah delima menurunkan tekanan intraokular sebesar 28,20% , serbuk telur keong mas 31,93% dan kombinasi sebesar 36,46%. Tidak terdapat efek sinergisme dari kombinasi dosis 500mg/kg bb tikus ---- Glaucoma is an eye disorder characterized by increased intraocular pressure that can cause progressive and irreversible optic nerve damage. Pomegranate (Punica granatum L.) and golden apple snail eggs (Pomacea canaliculata) have been known to contain flavonoids and carotene pigments that have the potential to reduce intraocular pressure. This research was conducted to determine the decrease in intraocular pressure (IOP) in a glaucoma rat model with a combination of pomegranate extract (Punica granatum L.) and golden apple snail egg powder (Pomacea canaliculata). The dried pomegranate (Punica granatum L.) was extracted with 70% ethanol for 5 days. The liquid extract is then evaporated to form a thick extract. Squeezed golden apple snail eggs and dried the liquid in an oven at 50oC for 24 hours until a powder forms. This study used 6 test groups consisting of normal control, negative control, positive control, pomegranate extract group, golden apple snail egg powder group and combination group. Glaucoma was induced by prednisolone acetate 1% and a positive comparison of acetazolamide. Measurement of eye pressure using the schiotz tonometer. The results showed that the pomegranate extract reduced IOP by 28.20%, gold apple snail egg powder by 31.93% and a combination of 36.46%. There is no synergism effect of the dose combination 500mg/kg rat.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | antiglaukoma, delima (Punica granatum L.), telur keong mas (Pomacea canaliculata) ---- antiglaucoma, pomegranate (Punica granatum L). golden apple snail (Pomacea canaliculata) |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 02 Oct 2024 02:30 |
| Last Modified: | 02 Oct 2024 02:30 |
| URI: | http://repository.stfi.ac.id/id/eprint/1388 |
Actions (login required)
 |
View Item |
