YESI SUPARTIKA, - (2020) UJI AKTIVITAS AFRODISIAK EKSTRAK ETANOL HERBA SELEDRI (Apium graveolens L.) PADA TIKUS JANTAN GALUR WISTAR. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Disfungsi seksual merupakan kondisi yang menunjukkan adanya gangguan pada salah satu atau lebih aspek fungsi seksual. Penelitian ini bertujuan untuk mengetahui aktivitas ekstrak etanol herba seledri sebagai afrodisiak dan menetapkan dosis efektifnya. Hewan uji yang digunakan adalah tikus jantan dan tikus betina galur Wistar yang terbagi ke dalam 5 kelompok uji (n=3), terdiri dari kontrol negatif (Na-CMC), kontrol positif (Sildenafil Sitrat), dan 3 kelompok dosis ekstrak etanol herba seledri (100, 200 dan 300 mg/KgBB). Uji aktivitas afrodisiak dilakukan dengan menggunakan metode mating behaviour test. Prinsip kerja metode ini adalah dengan mengamati perilaku seksual hewan uji dengan melihat jumlah introduction, climbing, dan coitus. Pengamatan aktivitas seksual tikus dilakukan pada jam 18.00 selama 1 jam dengan alat bantu berupa perangkat Closed Circuit Television (CCTV). Hasil pengujian menunjukkan bahwa ekstrak etanol herba seledri dengan dosis 100 mg/KgBB, 200 mg/KgBB dan 300 mg/KgBB memiliki aktivitas afrodisiak yang ditandai dengan peningkatan aktivitas introduction dan climbing. Namun, tidak adanya perbedaan yang bermakna (p>0,05) antara kelompok positif dengan kelompok uji ekstrak etanol dosis 300 mg/KgBB sehingga memungkinkan bahwa ekstrak etanol herba seledri dengan dosis 300 mg/KgBB memiliki aktivitas yang hampir sama dengan kelompok positif. ---- Sexual dysfunction is a condition that indicates a disturbance in one or more aspects of sexual function. This study aims to determine the activity of the ethanol extract of celery as an aphrodisiac and determine its effective dosage. The test animals used were male and female Wistar rats which were divided into 5 test groups (n = 3), consisting of a negative control (Na-CMC), a positive control (Sildenafil Citrate), and 3 groups of doses of ethanol extract of celery herb (100, 200 and 300 mg/Kgbw). The aphrodisiac activity test was carried out using the mating behavior test method. The working principle of this method is to observe the sexual behavior of the test animals by observing the amount of introduction, climbing, and coitus. Observation of the sexual activity of rats was carried out at 6:00 p.m. for 1 hour using a closed circuit television (CCTV) device. The test results showed that the ethanol extract of celery herb with a dose of 100 mg/ Kgbw, 200 mg/Kgbw and 300 mg/Kgbw had aphrodisiac activity which was marked by increased introduction and climbing activities. However, there was no significant difference (p> 0.05) between the positive group and the ethanol extract test group at a dose of 300 mg/Kgbw, so it is possible that the celery herbs ethanol extract at a dose of 300 mg/Kgbw has almost the same activity as the positive group.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Ekstrak herba seledri (Apium graveolens L.), afrodisiak, introduction, climbing, coitus. ----Extract of celery (Apium graveolens L.), aphrodisiac, introduction, climbing, coitus. |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 02 Oct 2024 02:39 |
| Last Modified: | 02 Oct 2024 02:39 |
| URI: | http://repository.stfi.ac.id/id/eprint/1382 |
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