RISKY NEIRUL NISA, - (2020) POLA PENGGUNAAN OBAT DAN GAMBARAN KLINIS PASIEN DALAM PENGAWASAN (PDP) COVID-19 DI RAWAT INAP SALAH SATU RUMAH SAKIT UMUM DAERAH RUJUKAN PROVINSI JAWA BARAT PERIODE MARET-JUNI TAHUN 2020. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Penyakit baru Coronavirus Disease 2019 (COVID-19) disebabkan virus SARSCoV-2 dapat menginfeksi sistem pernapasan, dengan gejala dari ringan seperti demam, batuk, dan nyeri tenggorokan hingga pneumonia berat dan ARDS (Acute Respiratory Distress Syndrome). Obat off-label digunakan di Indonesia untuk pengobatan, sesuai dengan pedoman yang dibuat berdasarkan WHO. Gambaran klinis pasien mempengaruhi pola penggunaan obat, sehingga perlu diketahui hubungan antara keduanya. Penelitian ini bertujuan mengetahui pola penggunaan obat yang sesuai dengan pedoman dan gambaran klinisnya di salah satu RSUD rujukan COVID-19, berdasarkan kajian retrospektif pada 102 sampel pasien inklusi dengan metode purposive sampling, dilanjutkan dengan pengolahan data secara statistik deskriptif dan Chi-square. Gambaran klinis pada pasien dalam pengawasan COVID-19 berdasarkan hasil laboratorium menunjukan adanya kenaikan pada nilai leukosit, nilai neutrofil, dan nilai CRP, sementara nilai limfosit mengalami penurunan dan menurut hasil rontgen toraks (80,39%) pasien mengalami pneumonia. Pola penggunaan obat antivirus oseltamivir (29,07%) paling banyak digunakan, dengan pola kombinasi antara antivirus bersama 2 antibiotik yaitu azitromisin dan levofloxacin (30,10%). Hasil penelitian penggunaan obat menunjukan kesesuaian dengan pedoman Informatorium BPOM (60,38%) dan pedoman tatalaksana COVID-19 edisi 2 (60,06%). Berdasarkan nilai hasil statistik Chi-square <0,05, menunjukkan terdapat pengaruh pola penggunaan kombinasi obat terhadap gambaran klinis berdasarkan lama rawat inap pasien. --- The new Coronavirus Disease 2019 (COVID-19) caused by the SARS-CoV-2 virus can infect the respiratory system, with symptoms ranging from mild such as fever, cough, and sore throat to severe pneumonia and ARDS (Acute Respiratory Distress Syndrome). Off-label drugs are used in Indonesia for treatment, according to the guidelines made according to WHO. The clinical picture of the patient affects the pattern of drug use, so it is necessary to know the relationship between the two. This study aims to determine the pattern of drug use by the guidelines and clinical picture in one of the COVID-19 referral hospitals, based on a retrospective study of 102 samples of inclusion patients using a purposive sampling method, followed by data processing using descriptive statistics and Chi-square. The clinical picture in patients under COVID-19 surveillance based on laboratory results showed an increase in leukocyte, neutrophil, and CRP values, while lymphocyte values decreased and according to chest X-rays (80.39%) patients had pneumonia. The pattern of using the antiviral drug oseltamivir (29.07%) was the most widely used, with a combination pattern of antiviral drugs with 2 antibiotics, namely azithromycin and levofloxacin (30.10%). The results of the research on drug use show compliance with the BPOM Informatorium guidelines (60.38%) and the COVID-19 management guidelines 2nd edition (60.06%). Based on the value of the Chi-square statistical value <0.05, it shows that there is an effect of the pattern of using drug combinations on the clinical picture based on the length of stay of the patient.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Coronavirus Disease 2019 (COVID-19), penggunaan obat, gambaran klinis. --- Coronavirus Disease 2019 (COVID-19), drug use, clinical features. |
| Subjects: | R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 03 Oct 2024 07:36 |
| Last Modified: | 03 Oct 2024 07:36 |
| URI: | http://repository.stfi.ac.id/id/eprint/1352 |
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