RAFINA SAQOFA, - (2020) PERBANDINGAN MODEL KOMPARTEMEN ETIL p-METOKSISINAMAT (EPMS) STANDAR DAN EPMS ISOLAT ASAL RIMPANG KENCUR (Kaempferia galanga L) PADA TIKUS WISTAR JANTAN. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Etil p-metoksisinamat (EPMS) merupakan zat aktif dari rimpang kencur yang memiliki khasiat yang banyak, tetapi belum diedarkan di pasaran. Salah satu alasan EPMS belum beredar di pasaran karena belum ada data mengenai farmakokinetika dan pemodelan farmakokinetik dari EPMS. Tujuan penelitian ini adalah menetapkan model kompartemen serta laju absorpsi, laju distribusi, dan laju eliminasi dari EPMS standar dan EPMS isolat rimpang kencur pada tikus wistar jantan sebagai hewan uji. Suspensi EPMS standar dan EPMS isolat rimpang kencur diberikan kepada hewan uji secara peroral, kemudian dilakukan pengambilan sampling plasma darah pada waktu – waktu yang sudah ditetapkan. Kadar EPMS diukur menggunakan HPLC pada panjang gelombang maksimum 309 nm dengan fase gerak metanol:asam fosfat 0,1% (70:30). Penetapan model kompartemen dan penentuan parameter farmakokinetika dianalisis dengan metode farmakokinetika linier dengan menggunakan software Farmakomatic. Dari hasil pengujian diperoleh informasi bahwa EPMS standar dan EPMS isolat rimpang kencur menunjukkan model kompartemen dua terbuka. Laju absorpsi, laju distribusi dan laju eliminasi EPMS Standar berturut – turut yaitu 0,946 μg/ml/jam; 0,849 μg/ml/jam; 0,849 μg/ml/jam sedangkan EPMS isolat rimpang kencur yaitu 1,034 μg/ml/jam; 1,006 μg/ml/jam; 1,006 μg/ml/jam. Dari hasil penelitian ini dapat disimpulkan bahwa proses absorpsi berjalan lebih cepat dibandingkan distribusi dan eliminasi. --- Ethyl p-methoxycinamate (EPMC) is an active substance from galanga rhizome which has many benefits, but has not been deployed in the market. One of the reasons EPMC has not been on the market yet is that there is no data on the pharmacokinetics and pharmacokinetic modeling of the EPMC. The purpose of this research was to determine the compartmen model and absorption rate, distribution rate, and elimination rate of standard EPMC and EPMC galanga rhizome isolate in male Wistar rats as test animals. The suspension of standard EPMC suspension and EPMC galanga rhizome isolate were given to the test animals orally, then blood plasma samples were taken at predetermined times. EPMC levels were measured using HPLC at a maximum wavelength of 309 nm with metanol:phosphoric acid 0,1% (70:30) as mobile phase. Determination of compartement models and pharmacokinetic parameters were analyzed using linear pharmacokinetic methods which was using the pharmakomatic software. Based on the results, it was found that the standard EPMC and EPMC galanga rhizome isolate showed an open two compartement model. The absorption rate, distribution rate, and elemination rate of the standard EPMC respectively are 0,946 μg/ml/hour; 0,849 μg/ml/hour; 0,849 μg/ml/hour while EPMC galanga rhizome isolate are 1,034 μg/ml/hour; 1,006 μg/ml/hour; 1,006 μg/ml/hour. Based on the results of this study, it can be concluded that the absorption process runs faster than distribution and elimination.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | Etil p-Metoksisinamat, Farmakokinetik, Kompartemen, laju absorpsi, laju distribusi, laju eliminasi. --- Ethyl p-methoxycinnamate, Pharmacokinetics, Compartement, Absorption rate, Distribution rate, Elimination rate. |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 04 Oct 2024 01:18 |
| Last Modified: | 04 Oct 2024 01:18 |
| URI: | http://repository.stfi.ac.id/id/eprint/1346 |
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