INDRIANI YUNIAR, - (2020) STUDI LITERATUR PENGARUH PEMBENTUKAN KOKRISTAL MENGGUNAKAN KOFORMER ASAM KARBOKSILAT DENGAN METODE SOLVENT EVAPORATION DAN SOLVENT DROP GRINDING TERHADAP BIOAVAILABILITAS ZAT AKTIF. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Kelarutan merupakan faktor fisikokimia penting yang mempengaruhi bioavailabilitas dan efektivitas terapi obat. Sekitar 40% atau lebih dari kandidat obat yang tersedia memiliki kelarutan yang rendah dalam air sehingga kelarutan dari zat aktif perlu ditingkatkan agar bioavailabilitasnya ikut meningkat, salah satunya dengan cara teknik kokristalisasi. Dalam studi ini akan dikemukakan review terkait pengaruh pembentukan kokristal zat aktif yang memiliki kelarutan rendah dalam air menggunakan koformer golongan asam karboksilat dengan metode solvent evaporation dan solvent drop grinding terhadap peningkatan bioavailabilitas. Zat aktif yang berhasil dibuat kokristal dengan peningkatan bioavailabilitas menggunakan koformer golongan asam karboksilat dengan metode solvent evaporation yaitu apixaban, aceclofenac, klorbipram, telmisartan, paliperidon, dan metronidazol, sedangkan untuk metode solvent drop grinding diantaranya ketokonazol, meloksikam, dipfluzin, asam galat, gliclazid, dan itrakonazol. Berdasarkan kajian pustaka, dapat disimpulkan bahwa pembentukan kokristal menggunakan koformer golongan asam karboksilat dengan metode solvent evaporation dan solvent drop grinding berpotensi meningkatkan bioavailabilitas zat aktif. Peningkatan terjadi karena terbentuk ikatan hidrogen antara zat aktif dengan koformernya serta adanya fase kristal baru yang menandakan kokristal telah terbentuk dan mengindikasikan peningkatan kelarutan sehingga bioavailabilitasnya ikut meningkat. --- Solubility is an important physicochemical factor affecting the bioavailability and effectiveness of drug therapy. About 40% or more of the available drug candidates have low solubility in water so that the solubility of the active substance needs to be increased so that its bioavailability is also increased, one of which is by means of the cocrystallization technique. In this study, a review will be presented related to the effect of cocrystal formation of active substances that have low water solubility using a carboxylic acid coformer with the solvent evaporation and solvent drop grinding methods on increasing bioavailability. Active substances that have been successfully made cocrystal with increased bioavailability using a carboxylic acid coformer with the solvent evaporation method are apixaban, aceclofenac, chlorbipram, telmisartan, paliperidone, and metronidazole, while the solvent drop grinding method includes ketoconazole, meloxicam, dipfluzine, gallic acid, and itraconazole. Based on literature review, it can be concluded that the formation of cocrystal using a carboxylic acid coformer using the solvent evaporation and solvent drop grinding methods has the potential to increase the bioavailability of active substances. The increase occurs due to the formation of hydrogen bonds between the active substance and the coformer as well as the presence of a new crystal phase which indicates the cocrystal has been formed and indicates an increase in solubility so that its bioavailability also increases. -
| Item Type: | Thesis (Skripsi) |
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| Uncontrolled Keywords: | bioavailabilitas, kokristal, koformer golongan asam karboksilat, solvent drop grinding, solvent evaporation. --- bioavailability, cocrystal, carboxylic acid group coformers, solvent drop grinding, solvent evaporation. |
| Subjects: | Q Science > Q Science (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 03 Oct 2024 03:45 |
| Last Modified: | 03 Oct 2024 03:45 |
| URI: | http://repository.stfi.ac.id/id/eprint/1303 |
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