AKTIVITAS ANTIOKSIDAN SEDIAAN SPRAY GEL DAUN FALOAK (Sterqulia quadrifida R.Br) DARI NUSA TENGGARA TIMUR

INDO ESSE, - (2020) AKTIVITAS ANTIOKSIDAN SEDIAAN SPRAY GEL DAUN FALOAK (Sterqulia quadrifida R.Br) DARI NUSA TENGGARA TIMUR. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Tanaman faloak (Sterculia quadrifida) memiliki aktivitas sebagai antioksidan. Daun faloak mengandung senyawa fenol, flavonoid, monoterpen dan steroid. Spray gel merupakan sediaan yang mempunyai keuntungan kenyamanan dalam pengunaan secara topical dan dalam menghantarkan sediaan terdispersi secara merata tanpa perlu kontak secara langsung. Penelitian ini bertujuan untuk menganalisis aktivitas antioksidan dari ektrak dengan variasi pelarut dan sediaan spray gel ekstrak daun faloak terhadap radikal bebas DPPH (2,2-diphenyl-1-picrylhydrazyl). Daun faloak diekstraksi dengan metode maserasi bertingkat dengan pelarut n-heksan, etil asetat dan etanol 96% dan dibuat dalam sediaan spray gel dengan 2 variasi konsentrasi ekstrak pada formula I dan II berturut-turut sebesar 31 mg, dan 69 mg. Aktivitas antioksidan ditentukan dengan metode DPPH yang memiliki prinsip penurunan nilai absorbansi yang sebanding dengan kenaikan konsentrasi senyawa antioksidan yang dinyatakan dengan IC50 (Inhibition Concentration). Hasil IC50 yang diperoleh berturut-turut ekstrak n-heksan; etil asetat; etanol 96% daun faloak, formula I, dan II yakni sebesar 51, 447 µg/mL; 49,440 µg/mL; 31, 482 µg/mL; 186, 907 µg/mL; dan 97,739 µg/mL. kesimpulan dari penelitian ini sediaan spray gel memiliki aktivitas antioksidan dan memenuhi persyaratan karakterisktik spray gel --- The plant faloak (Sterculia quadrifida) has antioxidant activity. The leaves of faloak contain phenolic compounds, flavonoids, monoterpenes and steroids. Spray gel is a preparation that has the advantage of being comfortable in topical use and in delivering evenly distributed preparations without the need for direct contact.This purpose of this study to analyze the antioxidant activity of the extract with various solvents and spray gel preparations of faloak leaf extract against free radical DPPH (2,2-diphenyl-1- picrylhydrazyl). The leaves of faloak were extracted by graded maceration method with n-hexane, ethyl acetate and 96% ethanol solvent and made in a spray gel preparation with 2 variations of extract concentrations in formula I and II, respectively 31 mg and 69 mg. Antioxidant activity is determined by the DPPH method which has the principle of decreasing the absorbance value which is proportional to the increase in the concentration of antioxidant compounds as stated by IC50 (Inhibition Concentration). The IC50 results obtained were n-hexane extract, respectively; ethyl acetate; ethanol 96% faloak leaves, formula I, and II, namely 51, 447 µg / mL; 49,440 µg / mL; 31, 482 µg / mL; 186, 907 µg / mL; and 97.739 µg / mL. The conclusion of this study is a spray gel preparation that has antioxidant activity and meets the requirements for the characteristics of spray gel

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	Daun faloak (Sterculia quadrifida), antioksidan, skrining fitokimia, spray gel --- Leaf faloak (Sterculia quadrifida), antioxidants, phytochemical screening, spray gel
Subjects:	Q Science > Q Science (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	03 Oct 2024 03:44
Last Modified:	03 Oct 2024 03:44
URI:	http://repository.stfi.ac.id/id/eprint/1302

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