FAUZAN AHMAD MUDZAKKIR, - (2020) UJI DISOLUSI PARTIKULAT KO-KRISTAL ETIL P-METOKSISINAMAT DENGAN KOFORMER ASAM TARTRAT MENGGUNAKAN VARIASI MEDIA DISOLUSI. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.
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Abstract
Etil p-metoksisinamat (EPMS) adalah hasil isolasi dari rimpang kencur (Kaemferia galanga L.) yang memiliki efek farmakologi sebagai anti inflamasi. EPMS memiliki kelarutan yang rendah dalam air sehingga dilakukan metode kokristalisasi dengan koformer asam tartrat untuk meningkatkan kelarutan EPMS dan pada penelitian ini dilakukan uji disolusi partikulat untuk mendapatkan data disolusi EPMS dengan koformer asam tartrat. Uji disolusi partikulat ko-kristal EPMS-Asam tartrat dilakukan dalam tiga variasi dapar (HCl pH 1,2; Asetat pH 4,5; Fosfat pH 6,8) menggunakan alat disolusi tipe II (Flight RC-3) dengan volume media sebanyak 900 mL dan temperatur 37±0,5℃. Hasil uji disolusi partikulat ko-kristal EPMS-Asam tartrat selama 60 menit dalam media dapar HCl, dapar asetat, dan dapar fosfat rata-rata EPMS terdisolusi berturut-turut sebanyak 24,09%, 29,86%, dan 22,9%. Pada EPMS murni selama 60 menit dalam media dapar HCL, dapar asetat, dan dapar fosfat EPMS terdisolusi berturut-turut sebanyak 4,47%, 4,10%, dan 3,81%, yang berarti hasil uji disolusi partikulat pada ko-kristal EPMS-Asam tartrat mengalami peningkatan dibanding EPMS murni. --- Ethyl p-methoxycinamat (EPMS) is the result of isolation from rhizome kencur (Kaemferia galanga L.) which has a pharmacological effect as an antiinflammatory. EPMS has low solubility in water, so the cocrystallization method was carried out with tartric acid coformer to increase the solubility of EPMS and in this research a particulate dissolution test was carried out to obtain EPMS dissolution data with tartric acid coformer. The dissolution test of co-crystalline EPMS-Tartaric acid was carried out in three buffer variations (HCl pH 1,2; Acetate pH 4.5; Phosphate pH 6.8) using a type II dissolution device (Flight RC3) with a medium volume of 900. mL and temperature 37 ± 0.5 ℃. The dissolution test results of co-crystalline EPMS-Tartaric acid for 60 minutes in HCl buffer, acetate buffer, and phosphate buffer average dissolved EPMS were 24.09%, 29.86%, and 22.9%, concecutively. In pure EPMS for 60 minutes in HCL buffer media, acetate buffer, and phosphate buffer EPMS dissolved as much as 4.47%, 4.10%, and 3.81% concecutively, which means that the test results of particulate dissolution in the co-crystals EPMS-Tartric acid has increased compared to pure EPMS.
| Item Type: | Thesis (Skripsi) |
|---|---|
| Uncontrolled Keywords: | etil p-metoksisinamat, asam tartat, ko-kristal, disolusi, dan variasi dapar. --- ethyl p-metoxycinnamate, tartaric acid, co-crystal, dissolution, buffer variation.. |
| Subjects: | Q Science > Q Science (General) R Medicine > R Medicine (General) |
| Divisions: | Program Studi S1 Farmasi |
| Depositing User: | pustakawan - - |
| Date Deposited: | 02 Oct 2024 04:32 |
| Last Modified: | 02 Oct 2024 04:32 |
| URI: | http://repository.stfi.ac.id/id/eprint/1288 |
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