PENINGKATAN KELARUTAN KOKRISTAL ETIL p-METOKSISINAMAT DENGAN METODE SOLVENT EVAPORATION MENGGUNAKAN KOFORMER UREA

FAKHRI HUMAIDI TRIYADI, - (2020) PENINGKATAN KELARUTAN KOKRISTAL ETIL p-METOKSISINAMAT DENGAN METODE SOLVENT EVAPORATION MENGGUNAKAN KOFORMER UREA. Skripsi thesis, Sekolah Tinggi Farmasi Indonesia.

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Abstract

Etil p-metoksisinamat (EPMS) merupakan zat aktif farmasi yang sukar larut air sehingga dapat membatasi disolusi dan bioavailabilitasnya. Untuk mengatasi permasalahan tersebut, metode kokristalisasi diterapkan terhadap EPMS dengan menggunakan urea sebagai koformer. Penelitian ini bertujuan untuk meningkatkan kelarutan dari EPMS melalui pembentukan kokristal EPMS menggunakan urea sebagai koformer dengan metode solvent evaporation. Kokristal EPMS-urea dikarakterisasi menggunakan spektrofotometer Fourier Transform Infrared (FT-IR), Powder X-Ray diffraction (PXRD), mikroskop digital, dan uji kelarutan di dalam air. Spektrum FTIR kokristal menunjukkan adanya interaksi berupa ikatan hidrogen antara EPMS dan urea. Difraktogram sinar-X senyawa kokristal EPMS-urea menunjukkan perubahan intensitas puncak. Morfologi kokristal menunjukkan perubahan visual setelah pembentukan kokristal. Peningkatan kokristal EPMS-urea 1:1, 1:2, 1:3, 2:1 secara berturut-turut sebesar 1,5; 1,6; 1,2; 1,3 kali dibandingkan dengan kelarutan EPMS murni. Berdasarkan penelitian ini, dapat disimpulkan bahwa EPMS berhasil dibentuk menjadi kokristal berdasarkan data interaksi berupa ikatan hidrogen antara EPMS dan urea, perubahan intensitas puncak, perubahan visual, dan mengalami peningkatan kelarutan hingga 1,6 kali-nya pada perbandingan kokristal EPMSurea 1:2. --- Ethyl p-methoxycinamate (EPMC) is a water-insoluble active pharmaceutical ingredients so it has poor dissolution and bioavailability. To overcome this problem, the cocrystallization method was applied to EPMC using urea as a coformer. The aim of this study was to increase the solubility of EPMC through the formation of EPMC cocrystal using urea as a coformer by the solvent evaporation method. EPMC-urea cocrystals were characterized using a Fourier Transform Infrared (FT-IR) spectrophotometer, Powder X-Ray Diffraction (PXRD), digital microscopy, and solubility tests in water. The FTIR spectrum of the cocrystal showed the interaction in the form of hydrogen bonds between EPMC and urea. X-ray diffractogram of the EPMC-urea cocrystal compound showed changes in peak intensity. The morphology of the cocrystal showed visual changes after cocrystal formation. The increase in EPMC-urea cocrystal 1:1, 1:2, 1:3, 2:1 respectively by 1.5; 1.6; 1,2; 1.3 folds compared to the solubility of EPMC. It can be concluded that EPMC was successfully formed into cocrystal based on data interaction in the form of hydrogen bonds between EPMC and urea, changes in peak intensity, visual changes, and increased solubility up to 1,6 folds at a ratio of EPMC-urea 1:2.

Item Type:	Thesis (Skripsi)
Uncontrolled Keywords:	etil p-metoksisinamat, urea, kokristal, solvent evaporation. --- ethyl p-metoxycinnamate, urea, cocrystals, solvent evaporation
Subjects:	Q Science > Q Science (General) R Medicine > R Medicine (General)
Divisions:	Program Studi S1 Farmasi
Depositing User:	pustakawan - -
Date Deposited:	02 Oct 2024 04:25
Last Modified:	02 Oct 2024 04:25
URI:	http://repository.stfi.ac.id/id/eprint/1285

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